Circulating microRNAs in Sepsis-Associated Acute Kidney Injury: A Systematic Review
| Author | Seyed Majid Seyedalagheband | en |
| Author | Navid Nuraei | en |
| Author | Kamal Fani | en |
| Author | Maedeh Karimian | en |
| Author | Marzieh Shahrabi | en |
| Orcid | Seyed Majid Seyedalagheband [0009-0008-1240-739X] | en |
| Orcid | Navid Nuraei [0000-0001-7226-7618] | en |
| Orcid | Kamal Fani [0000-0002-7921-257X] | en |
| Orcid | Maedeh Karimian [0000-0003-4854-7470] | en |
| Orcid | Marzieh Shahrabi [0009-0002-5298-9132] | en |
| Issued Date | 2026-10-31 | en |
| Abstract | Context: Sepsis-associated acute kidney injury (AKI) is a common and serious complication in critically ill patients and is associated with increased mortality in the intensive care unit. Circulating microRNAs (miRNAs) have attracted attention as potential biomarkers for the early detection and prognosis of sepsis-associated AKI. This systematic review aimed to evaluate the role of circulating miRNAs in sepsis-associated AKI and summarize current evidence regarding their diagnostic, prognostic, and potential functional significance. Evidence Acquisition: Web of Science, PubMed, and Scopus were systematically searched for relevant studies. Two reviewers independently extracted the data and assessed the methodological quality of the included studies using the Newcastle-Ottawa Scale. Results: Across the reviewed studies, changes in circulating miRNA expression were associated with the early identification of sepsis-associated AKI and the prediction of subsequent clinical outcomes. However, expression profiles varied considerably among individual miRNAs. Members of the miR-21 family, miR-26a-5p, miR-106a, miR-107, miR-210, miR-494, and miR-155 were frequently reported to be upregulated, whereas miR-22 - 3p, miR-23a-3p, miR-15a-5p, miR-150 - 5p, miR-29b-3p, miR-103a-3p, and miR-205 showed reduced expression. Restoring miR-22 - 3p and miR-214 had protective effects in preclinical models. Reverse transcription-quantitative polymerase chain reaction and microarrays were the most commonly used techniques for miRNA quantification. Nevertheless, relatively small study populations and short follow-up durations limit interpretation of the evidence and its applicability to clinical practice. Discussion: Dysregulated circulating miRNAs may serve as candidate biomarkers for the early detection and prognosis of sepsis-associated AKI. However, the evidence remains preliminary and requires confirmation in larger, longitudinal clinical trials to determine whether miRNA-based approaches could have future therapeutic applications. | en |
| DOI | https://doi.org/10.5812/jcma-175265 | en |
| URI | https://brieflands.com/journals/jcma/articles/175265 | en |
| Keyword | Sepsis | en |
| Keyword | Acute Kidney Injury | en |
| Keyword | microRNA | en |
| Keyword | Biomarker | en |
| Keyword | Prognosis | en |
| Publisher | Brieflands | en |
| Title | Circulating microRNAs in Sepsis-Associated Acute Kidney Injury: A Systematic Review | en |
| Type | Systematic Review | en |
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