Association Between IL-10 Gene Promoter Polymorphisms (-592 A/C, -819 T/C, -1082 A/G) and Susceptibility to HBV Infection in an Iranian Population
| Author | Bita Moudi | en |
| Author | Zahra Heidari | en |
| Author | Hamidreza Mahmoudzadeh-Sagheb | en |
| Author | Mohammad Hashemi | en |
| Author | Malihe Metanat | en |
| Author | Soheila Khosravi | en |
| Author | Parisa Farrokh | en |
| Orcid | Zahra Heidari [0000-0002-3401-1619] | en |
| Issued Date | 2016-02-01 | en |
| Abstract | Background: IL-10 can play a vital role in immune response against HBV. Three biallelic SNPs from the transcription start site control the transcription of the IL-10 gene. An association between susceptibility to HBV and IL-10 polymorphisms has been suggested in patients with HBV infection. Objectives: The present study was designed to study the association between polymorphisms in interleukin-10 (-1082 A/G, -819 T/C and -592 A/C) promoter gene and chronic hepatitis B virus (HBV) infection. Patients and Methods: 221 chronically infected patients and 200 healthy control subjects were enrolled in the study. Three biallelic (-1082 A/G, -819 T/C and -592 A/C) polymorphisms in the IL-10 promoter gene were determined by PCR-RFLP method. Results: Persistent HBV infection was associated with IL-10-1082 AG (P = 0.001) and GG (P = 0.004) genotypes and G (P = 0.000) allele. IL-10-819 T/C and -592 A/C genotype and allele frequencies did not show any correlation with the risk of chronic hepatitis B infection. Conclusions: These results suggest that polymorphisms in interleukin-10 gene promoter influence clinical outcome of HBV infection and susceptibility to HBV infection. | en |
| DOI | https://doi.org/10.5812/hepatmon.32427 | en |
| Keyword | Chronic Hepatitis B | en |
| Keyword | Interleukin-10 | en |
| Keyword | Single Nucleotide Polymorphism | en |
| Publisher | Brieflands | en |
| Title | Association Between IL-10 Gene Promoter Polymorphisms (-592 A/C, -819 T/C, -1082 A/G) and Susceptibility to HBV Infection in an Iranian Population | en |
| Type | Research Article | en |
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