Carbapenem-Resistant Bacteria and Laboratory Detection Methods

Abstract

Carbapenemase producing bacteria frequently possess resistance mechanisms to a wide-range of antibacterial agents, and are associated with high mortality and morbidity rates. Some enzymes like extended-spectrum β-lactamase (ESBL), New Delhi metallo-beta-lactamase-1 (NDM-1), Klebsiella pneumoniae carbapenemase (KPC), and OXA-producing Enterobacteriaceae are very important in frequently isolated nosocomial bacteria, which cause resistant to many classes of drugs. NDM-1 or KPCs, is a worldwide health problem which is slowly increasing. There is no vaccine to prevent infections produced by carbapenem-resistant bacteria.