Optional Modalities for Treatment of Patients with Severe Crimean-Congo Hemorrhagic Fever

Abstract

Crimean-Congo hemorrhagic fever (CCHF) is an acute viral hemorrhagic fever caused by the Nairovirus in the family of Bunyaviridae, transmitted to humans by the bite of the Hyalomma tick or by direct contact with blood or tissue of an infected animal or human. CCHF is a severe disease with a high mortality rate ranging from 2% to 70%. Early diagnosis and treatment of CCHF infection is critical to rescue the patients and control the disease. The important approach to treatment of CCHF is based on general supportive measures, monitoring of the patients hematologic and coagulation status, with replacement of cells and other factors as needed, and the prompt use of ribavirin. In this article, we underline current therapeutic approaches to CCHF infection.