Development and Optimization of Dissolvable Polymeric Microneedle Patch for Transdermal Delivery of Lawsone
| Author | Marzieh Sajadi Bami | en |
| Author | Shayan Fakhraei Lahij | en |
| Author | Hamid Mobedi | en |
| Author | Mehrdad Hamidi | en |
| Author | Reza Vahidi | en |
| Author | Payam Khazaeli | en |
| Orcid | Mehrdad Hamidi [0000-0001-7977-5252] | en |
| Orcid | Payam Khazaeli [0000-0002-5920-5815] | en |
| Issued Date | 2026-02-28 | en |
| Abstract | Background: Transdermal drug delivery by means of polymeric microneedles (PMNs) offers the advantage of overcoming some of the disadvantages of oral medication, such as first-pass metabolism, through painless, controlled drug release. Lawsone, isolated from Lawsonia inermis, exhibits reported antioxidant, anti-inflammatory, antimicrobial, and antitumor properties, suggesting its use as a promising candidate for topical application. Objectives: Fabrication and optimization of hyaluronic acid-carboxymethylcellulose (HA-CMC) PMNs loaded with lawsone with respect to enhancing transdermal delivery and understanding release and physicochemical characteristics. Methods: Hyaluronic acid-carboxymethylcellulose-lawsone patches were prepared by micromolding. The Box-Behnken design approach was then utilized to identify the appropriate concentrations of carboxymethylcellulose (CMC) (0.15% to 0.35% w/w), hyaluronic acid (HA) (0.01% to 0.09% w/w), and polyethylene glycol 400 (PEG 400) (0.5% to 1.5% w/w), all of which are dependent on drug release after 90 minutes. Morphological examination was conducted using light and scanning electron microscopy (SEM). The levels of transepidermal water loss (TEWL), drug content, insertion rate, mechanical properties, and release of the patches were assessed. Results: The optimized formulation showed a cumulative release of 59.63% in 90 min, following Higuchi release kinetics. Polymeric microneedles showed uniform morphology, a failure force of 0.48 N, full penetration of 375 μm, and reversible changes in TEWL. Conclusions: Hyaluronic acid-carboxymethylcellulose PMNs offer a promising formulation strategy for the transdermal delivery of lawsone. This preliminary study establishes a biocompatible platform with potential for future development towards anti-inflammatory and antitumor therapies, pending further in vivo validation. | en |
| DOI | https://doi.org/10.5812/jjnpp-169497 | en |
| URI | https://brieflands.com/journals/jjnpp/articles/169497 | en |
| Keyword | Polymeric Microneedle | en |
| Keyword | Optimization | en |
| Keyword | Lawsone | en |
| Keyword | Transdermal Delivery | en |
| Publisher | Brieflands | en |
| Title | Development and Optimization of Dissolvable Polymeric Microneedle Patch for Transdermal Delivery of Lawsone | en |
| Type | Research Article | en |