Association Between Low Serum Vitamin D Levels and Sepsis: A Single-Center Study in Tehran, Iran
| Author | Masume Bayat | en |
| Author | Latif Gachkar | en |
| Author | Mahya Zahirnia | en |
| Author | Fahimeh Hadavand | en |
| Orcid | Fahimeh Hadavand [0000-0002-6565-1344] | en |
| Issued Date | 2021-05-29 | en |
| Abstract | Background: Vitamin D insufficiency is common in critically ill patients. It is hypothesized that vitamin D deficiency would be associated with sepsis in the critically ill. Thus, the present study aimed to investigate the association between vitamin D and sepsis severity. Method: In this cross-sectional study, patients with sepsis referring to a university hospital in Tehran, Iran, from February 2018 to March 2019 were included. Plasma concentrations of vitamin D in critically ill subjects admitted were assessed. Data were analyzed using SPSS version 20.0. P-values less than 0.05 were considered statistically significant. Results: Among the investigated patients, the mean serum level of vitamin D3 was 19.03 ± 13.08 ng/mL. The prevalence of vitamin D insufficiency in critically ill subjects with sepsis was 100% (150/150). Only sex (P = 0.01) indicated a significant association with vitamin D. Patients suffering from severe sepsis had lower levels of vitamin D compared to the patients with non-severe sepsis (P = 0.07). Conclusions: The present study showed that all critically ill patients studied had vitamin D insufficiency. In line with the biological evidence, the present study suggests that vitamin D deficiency may predispose patients to sepsis. Further studies are needed to establish the causes and mechanisms underlying these interpretations. | en |
| DOI | https://doi.org/10.5812/archcid.102926 | en |
| Keyword | Sepsis | en |
| Keyword | Vitamin D deficiency | en |
| Keyword | Iran | en |
| Publisher | Brieflands | en |
| Title | Association Between Low Serum Vitamin D Levels and Sepsis: A Single-Center Study in Tehran, Iran | en |
| Type | Research Article | en |
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