Intensity of HLA-A2 Expression Significantly Decreased in Occult Hepatitis B Infection

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AuthorAzam Askarien
AuthorGholam Hossein Hassanshahien
AuthorSeyed Razi Ghalebien
AuthorAbdollah Jafarzadehen
AuthorMaryam Mohiten
AuthorMasomeh Hajghanien
AuthorMohammad Kazemi Arababadien
Issued Date2014-06-01en
AbstractBackground: Occult hepatitis B infected (OBI) patients cannot eradicate hepatitis B virus (HBV)-DNA from their liver and peripheral blood, completely. Objectives: The main aim of this study was to investigate the rate of HLA-A2 expression on peripheral blood mononuclear cells (PBMCs) of patients with OBI. Materials and Methods: In this experimental study, intensity of HLA-A2 was measured on the PBMCs of 57 OBI patients and 100 HBsAg-/anti-HBc+/HBV-DNA samples were enrolled as controls; measurements were performed using the flow cytometry technique. Results: Flow cytometric analysis indicated that 19 (33.3%) OBI patients and 28 (28%) controls expressed HLA-A2 antigen on their PBMCs. There was no significant difference between the two groups regarding the rate of individuals expressing HLA-A2 antigen. Statistical analyses showed that the intensity of HLA-A2 expression significantly decreased in OBI patients (3.58 ± 0.1) in comparison to healthy controls (4.21 ± 0.25; P < 0.001). Conclusions: According to these results it can be concluded that decreased intensity of HLA-A2 on the PBMCs of OBI patients may lead to resistance of HBV in the patients.en
DOIhttps://doi.org/10.5812/jjm.10298en
KeywordOcculten
KeywordHepatitis Ben
KeywordInfectionen
KeywordHLA-A2en
KeywordDNAen
PublisherBrieflandsen
TitleIntensity of HLA-A2 Expression Significantly Decreased in Occult Hepatitis B Infectionen
TypeResearch Articleen

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