ATP-Binding Cassette Transporter A1 Polymorphisms and Haplotypes in Risk of Type 2 Diabetes
| Author | Ramin Saravani | en |
| Author | Hamid Reza Galavi | en |
| Author | Nasrin Ranjbar | en |
| Author | Ali Reza Alamdari | en |
| Orcid | Ramin Saravani [0000-0003-1941-3617] | en |
| Issued Date | 2017-01-31 | en |
| Abstract | Background: Type 2 diabetes (T2D) is one of the fastest growing diseases in the world and may be related to abnormalities in serum lipid levels. The ATP-binding cassette transporterA1 (ABCA1) is a transporter that exports lipids from cells. Objectives: The association between polymorphisms rs4149313 and rs2230806 of the ABCA1 gene in patients with T2D in Southeast of Iran was evaluated. Methods: Two hundred and fifty patients with T2D and the same number (250) of healthy control subjects were genotyped for two single nucleotide polymorphisms (SNPs) using the amplification-refractory mutation system-polymerase chain reaction (ARMS-PCR) method. Results: AA, AG, and GG genotype frequencies of the rs4149313 polymorphism were, respectively, 60, 20, and 20% in patients with T2D and 68.8, 21.6, and 9.6% in control subjects. The GG genotype and G allele differed significantly as a risk factor for T2D between patients with T2D and control groups (P < 0.001 and P < 0.0001, respectively). The frequencies of the rs2230806 genotypes did not differ significantly between the T2D and control groups (P > 0.05). The rs4149313/G-rs2230806/G (GG) haplotype differed significantly as a risk factor for T2D between the T2D and control groups (P = 0.0014, OR = 1.52, 95%CI = 1.18 - 1.96). Conclusions: The G allele of the ABCA1 rs4149313 polymorphism was related with a higher risk of T2D, but no relationship existed between the ABCA1 rs2230806 polymorphism and T2D in the study population. | en |
| DOI | https://doi.org/10.17795/gct-43677 | en |
| Keyword | Single Nucleotide Polymorphism | en |
| Keyword | ATP-Binding Cassette Transporters | en |
| Keyword | Diabetes Mellitus Type 2 | en |
| Keyword | Lipoproteins | en |
| Publisher | Brieflands | en |
| Title | ATP-Binding Cassette Transporter A1 Polymorphisms and Haplotypes in Risk of Type 2 Diabetes | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- gct-04-01-43677.pdf
- Size:
- 538.12 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF