Association of NTCP Gene Polymorphisms and Spontaneous Clearance of Hepatitis B Virus in Asia: A Meta-Analysis

Loading...
Thumbnail Image

Journal Title

Journal ISSN

Volume Title

Publisher

Brieflands

Abstract

Context: It is reported that NTCP (sodium taurocholate cotransporting polypeptide) gene polymorphisms are associated with spontaneous clearance of hepatitis B virus (HBV), but the results are contradictory. Therefore, the current meta-analysis aimed at systematically clarifying the association between NTCP gene polymorphisms and spontaneous clearance of HBV in Asia. Evidence Acquisition: PubMed, Embase, Web of Science, Scopus, China National Knowledge Infrastructure and China Wanfang Data were searched systematically for articles published before 09 August 2019. Results: A total of nine case-control studies were finally included in the current meta-analysis. The pooled results indicated that the NTCP gene rs2296651 A allele is a protective factor for spontaneous clearance of HBV (GG vs. GA+AA: odds ratio (OR) = 0.73, 95% confidence interval (CI) = 0.58 - 0.93; GG vs. GA: OR = 0.74, 95%CI = 0.59 - 0.93; G vs. A allele: OR = 0.74, 95%CI = 0.58 - 0.94). Conclusions: NTCP gene rs2296651 polymorphism is correlated with spontaneous clearance of HBV, while NTCP gene rs4646287 and rs7154439 variants are not associated with persistent HBV susceptibility.

Description

Keywords

Citation

URI

Endorsement

Review

Supplemented By

Referenced By