Low Prevalence of Hepatitis C Virus Infection Among HIV-Positive Patients: Data From a Large-Scale Cohort Study in Istanbul, Turkey
| Author | Ozlem Altuntas Aydin | en |
| Author | Mucahit Yemisen | en |
| Author | Hayat Kumbasar Karaosmanoglu | en |
| Author | Fatma Sargin | en |
| Author | Alper Gunduz | en |
| Author | Bahadir Ceylan | en |
| Author | Bilgul Mete | en |
| Author | Nail Ozgunes | en |
| Author | Dilek Yildiz Sevgi | en |
| Author | Resat Ozaras | en |
| Author | Fehmi Tabak | en |
| Orcid | Ozlem Altuntas Aydin [0000-0002-6508-7368] | en |
| Issued Date | 2014-08-01 | en |
| Abstract | Background: Rate of coinfection with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) varies in different countries. This may be attributable to common transmission routes as well as social, economic, and cultural factors. Objectives: The purpose of this study was to investigate the prevalence and risk factors of HCV infection among HIV-positive patients in Istanbul, Turkey. Patients and Methods: Since January 2006 to November 2013, 949 HIV-positive patients that were enrolled in this study by ACTHIV-IST (Action Against HIV in Istanbul) Study Group, which consists of five centers to follow up HIV-positive patients in Istanbul. Epidemiologic and clinical data were collected retrospectively from medical records and were transferred to an HIV database system. Results: Among 949 patients, 84% were men and the mean age was 37.92 ± 11.54 years (range, 17-79). The most frequent route of transmission was heterosexual intercourse (48.8%), followed by men having sex with men (30.5%). Only nine patients (0.9%) had history of injection drug use (IDU). The prevalence of HIV/HCV coinfection was 0.9% (9:949). The IDU rate was 44.4% (4:9) in patients with HIV/HCV coinfection (three of them were not Turkish citizens), whereas this rate was only 0.6% (5:881) in patients with only HIV infection (P < 0.01). Genotypes 1b, 2a/2c, and 3 were determined in five, one, and two patients, respectively. Genotype could not be determined in one patient. History of residence in a foreign country (P < 0.01) and imprisonment (P < 0.01) were also considered as risk factors in terms of HIV/HCV coinfection. Conclusions: Prevalence of HIV/HCV coinfection is considerably low in Turkey. The extremely rare prevalence of IDU might have a role in this low prevalence. | en |
| DOI | https://doi.org/10.5812/hepatmon.18128 | en |
| Keyword | Human Immunodeficiency Virus | en |
| Keyword | Hepatitis C Virus | en |
| Keyword | Prevalence | en |
| Keyword | Turkey | en |
| Publisher | Brieflands | en |
| Title | Low Prevalence of Hepatitis C Virus Infection Among HIV-Positive Patients: Data From a Large-Scale Cohort Study in Istanbul, Turkey | en |
| Type | Research Article | en |
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