Effects of Alcoholic Extract of <i>Myrtus communis </i>L. on the Hypothalamic-Pituitary-Thyroid Axis in Rats
| Author | Saeed Changizi-Ashtiyani | en |
| Author | Mehrdad Shariati | en |
| Author | Mokhtar Mokhtari | en |
| Author | Davoud Moghadamnia | en |
| Author | Moslem Fereidooni | en |
| Issued Date | 2015-09-28 | en |
| Abstract | Background:: Myrtus communis leaves have the potential to affect thyroid hormone functions. Objectives:: In this study, the effects of hydroalcoholic extract of M. communis on the hypothalamus-pituitary-thyroid axis and histological changes were studied. Materials and Methods:: In this experimental study, 40 male rats were divided in 5 groups (n = 8): control, sham, and three experimental groups which received the extract of M. communis leaves in a minimal (0.75 mg/kg), Medium (1.5 mg/kg) and maximal amounts (3 mg/kg), respectively. At the end of the 15th day blood samples were collected to measure triiodothyronine (T3), thyroxine (T4) and thyroid-stimulating hormone (TSH) and to study thyroid gland tissue Results:: Serum levels of T4 and TSH in groups receiving maximum dose of the extract showed a significant decrease compared to sham group (P < 0.05). Conclusions:: It is probable that some compounds in the alcoholic extract of M. communis leaves may be cause changes in serum TSH concentration and thyroid hormones. | en |
| DOI | https://doi.org/10.17795/zjrms-4025 | en |
| Keyword | Thyroid | en |
| Keyword | Pituitary | en |
| Keyword | Triiodothyronine | en |
| Keyword | Thyroxine | en |
| Keyword | Thyroid-stimulating hormone | en |
| Keyword | Rat | en |
| Keyword | <i>Myrtus communis</i> leaf | en |
| Publisher | Brieflands | en |
| Title | Effects of Alcoholic Extract of <i>Myrtus communis </i>L. on the Hypothalamic-Pituitary-Thyroid Axis in Rats | en |
| Type | Brief Report | en |
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