Antibacterial Activity and Composition of the Fermentation Broth of <i>Streptomyces Parvus</i> 33
| Author | Wenjuan Zhang | en |
| Author | Saijian Ma | en |
| Author | Chao An | en |
| Author | Wenjiao Xue | en |
| Issued Date | 2017-08-31 | en |
| Abstract | Background: Microorganisms represent a potentially valuable source of biologically significant compounds that should be explored for their potential agrochemical use. Objectives: The compounds ZM-1 and ZM-2 were isolated from the extract of the fermentation broth of Streptomyces parvus 33 by bioassay-guided fractionation. Methods: The compound ZM-1 was isolated in the form of a clear single crystal for the first time, and identified as holomycin via X-ray crystallography. The compound ZM-2 was characterized by IR, 1H-NMR, 13C-NMR, DEPT (90° and 135°), and MS analyses. Results: The compound ZM-1 showed a strong antibacterial activity against the tested bacteria, and its value of minimum inhibitory concentration (MIC) was greater than that of the positive control Ampicillin. The compound ZM-1 also exhibited significant antimicrobial activities against some plant pathogenic fungi. Nevertheless, ZM-2 showed no activities against the tested bacteria and plant pathogenic fungi. Conclusions: The compound ZM-1 was isolated in the form of a clear single crystal for the first time, and identified as holomycin via X-ray crystallography. Streptomyces parvus 33 is a newly discovered producer of holomycin. ZM-1 showed a strong antibacterial activity against the tested bacteria. Therefore, the compound ZM-1 is a valuable lead compound for the development of agricultural fungicides while acts against bacteria, as well. | en |
| DOI | https://doi.org/10.5812/jjm.12677 | en |
| Keyword | Anti-Bacterial Agents | en |
| Keyword | Crystal | en |
| Keyword | <i>Streptomyces</i> | en |
| Publisher | Brieflands | en |
| Title | Antibacterial Activity and Composition of the Fermentation Broth of <i>Streptomyces Parvus</i> 33 | en |
| Type | Research Article | en |
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