Successful Treatment of "Psoriasis Vulgaris and Subsequent Erythrodermic Psoriasis" with The Acyl-Flavonoid, InflAQ: Case Report with a Review of the Literature

Abstract

Psoriasis is an intricate long-term inflammatory skin disease with a high outbreak rate and associated comorbidity. Literature reviews show the usefulness of various flavonoid (topical) formulations for treating/preventing psoriasis. However, both the low bioavailability and weak skin penetration of flavonoids significantly limit their practical application in the management of this autoimmune disease. A 36-year-old married woman presented with a ~26-year history of redness/erythema, thickness/induration, and scaling/desquamation of widespread psoriatic skin lesions, almost on the face/neck as well as upper/lower extremities. One month after the start of the treatment/intervention with the acylated-flavonoid, InflAQ, monotherapy, a remarkable improvement in the clinical appearance was achieved, specifically on the face and lower extremities. Two months later, erythema, scaling, and thickness were substantially reduced in places where the formulated InflAQ cream was applied. Using a modified form of quercetin (as a pro-drug/quercetin), we report the successful treatment of a female patient affected with Psoriasis vulgaris.