Vitamin D Level, Weight, Height, and BMI Among Children with Cystic Fibrosis: A Retrospective Study
| Author | Mitra Ahmadi | en |
| Author | Mohammadreza Mirkarimi | en |
| Author | Shabnam Khanifar | en |
| Author | Hazhir Javaherizadeh | en |
| Author | Mohsen Ali Samir | en |
| Orcid | Mitra Ahmadi [0000-0001-8215-9784] | en |
| Orcid | Mohammadreza Mirkarimi [0000-0001-7617-1322] | en |
| Orcid | Shabnam Khanifar [0000-0001-7898-4589] | en |
| Orcid | Hazhir Javaherizadeh [0000-0001-7898-4589] | en |
| Orcid | Mohsen Ali Samir [0000-0003-4938-2647] | en |
| Issued Date | 2024-04-30 | en |
| Abstract | Background: Cystic fibrosis (CF) stands as the most common chronic multisystem and fatal inherited disease. Objectives: The present study aimed to assess the clinical presentation and laboratory findings in children with CF. Methods: This retrospective cross-sectional study reviewed the records of CF patients over a 2-year period beginning in 2018. The diagnosis of CF was confirmed based on clinical manifestations, sweat chloride tests, or genetic studies. Children aged ≥ 2 years were included; nevertheless, patients without sweat chloride tests or genetic studies were excluded. This study recorded demographic features, gastrointestinal manifestations, vitamin D levels, and the number of hospital admissions. A pediatric gastroenterologist conducted fecal elastase and stool fat analyses to evaluate pancreatic insufficiency. Vitamin D levels < 30 ng/mL were considered vitamin D insufficiency; however, levels < 20 ng/mL indicated a vitamin D deficiency. A P-value < 0.05 was considered statistically significant. Results: This study included 59 children (37 male and 22 female) in the study. Low weight, height, and body mass index (BMI) percentiles (< 5) were most frequently observed. Approximately 86.4% of the patients had consanguineous parents, and 40.7% had affected siblings. Failure to thrive (FTT) (49.2%) and recurrent respiratory infections (45.8%) were the most common clinical presentations. A majority (57.7%) of the patients were diagnosed before the age of 1 year. The mean number of admissions in the past 2 years was 3, and 58% of the cases reported gastrointestinal symptoms. A significant correlation was observed between vitamin D levels and the number of hospital admissions (Pearson coefficient = 0.298, P = 0.042). Conclusions: In this study, there was a high prevalence of vitamin D insufficiency and FTT in children with CF. Additionally, there was a significant correlation between vitamin D levels and the number of hospital admissions over a 2-year period. | en |
| DOI | https://doi.org/10.5812/jjcdc-139033 | en |
| Keyword | Cystic Fibrosis | en |
| Keyword | Vitamin D | en |
| Keyword | Ileus | en |
| Keyword | Inflammatory Markers | en |
| Keyword | Pancreas | en |
| Publisher | Brieflands | en |
| Title | Vitamin D Level, Weight, Height, and BMI Among Children with Cystic Fibrosis: A Retrospective Study | en |
| Type | Research Article | en |
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