Therapeutic Effect of Gallic Acid Against Paraquat-Induced Lung Injury in Rat
| Author | Mojtaba Kalantar | en |
| Author | Mohammad Javad Khodayar | en |
| Author | Heibatullah Kalantari | en |
| Author | Layasadat Khorsandi | en |
| Author | Ali Asghar Hemmati | en |
| Orcid | Mohammad Javad Khodayar [0000-0001-9518-1286] | en |
| Orcid | Ali Asghar Hemmati [0000-0003-2085-8437] | en |
| Issued Date | 2018-08-31 | en |
| Abstract | Background: Paraquat (PQ), a potent herbicide, is extremely toxic to humans when exposed orally and it is known to induce lung injury via a redox cyclic reaction. Objectives: The current study aimed at examining the effect of gallic acid (GA), a polyphenolic compound, which is a constituent of plant-derived foods, against PQ-induced lung injury and pulmonary fibrosis in association with its antioxidant activity. Methods: Male rats were randomly divided into 5 experimental groups each containing 14 rats. Group 1 received normal saline for 21 days. Group 2 received a single dose of oral administration of PQ (50 mg/kg, only on first day) for 21 days. Groups 3 to 5 were treated with different doses of GA after PQ ingestion for 21 days. Seven animals from each group were sacrificed on the days 7 and 21. Results: The results showed that paraquat gavage, significantly enhanced the inflammatory and fibrotic modifications, hydroxyproline (HP), levels of malondialdehyde (MDA), main proinflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and transforming growth factor (TGF)-β1 as a pro-fibrotic mediator in lung tissue. It also, significantly diminished enzymatic antioxidant amounts such as catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx) activity and non-enzymatic amounts such as glutathione (GSH) content in the rat lung tissue. However, after GA treatment all of these biochemical indices were diminished with a dose dependent manner and histopathological alterations were also close to normal status. Conclusions: The current study indicated that the GA improved the PQ-induced lung injury and prevented the process of pulmonary fibrosis via its antioxidant and immunomodulatory properties. | en |
| DOI | https://doi.org/10.5812/jjnpp.12450 | en |
| Keyword | Paraquat | en |
| Keyword | Pulmonary Fibrosis | en |
| Keyword | Gallic Acid | en |
| Keyword | Oxidative Stress | en |
| Publisher | Brieflands | en |
| Title | Therapeutic Effect of Gallic Acid Against Paraquat-Induced Lung Injury in Rat | en |
| Type | Research Article | en |