A Cross-sectional Study on the Role of <i>Rotavirus</i> and Microbial Co-infection in Children with Acute Diarrhea in Vietnam
| Author | Khai Quang Tran | en |
| Author | Hung Hoang Tuan Nguyen | en |
| Author | Van Hung Pham | en |
| Author | Nghia Quang Bui | en |
| Author | Tho Kieu Anh Pham | en |
| Author | Toan Hoang Ngo | en |
| Author | Phuong Minh Nguyen | en |
| Orcid | Khai Quang Tran [0000-0002-7840-7818] | en |
| Orcid | Phuong Minh Nguyen [0000-0002-3857-9420] | en |
| Issued Date | 2024-01-31 | en |
| Abstract | Background: Rotavirus is the leading cause of acute diarrhea in children. Understanding co-infections with other bacterial or viral microorganisms alongside Rotavirus is crucial. Objectives: This study aimed to determine the frequency distribution of Rotavirus infections and related co-infections in children with acute diarrhea. Additionally, it sought to compare 2 groups: Those with Rotavirus mono-infection and those with microbial co-infections in terms of clinical and laboratory characteristics. Methods: In this cross-sectional study, we collected a total of 171 rectal swabs at Can Tho Children′s Hospital, Can Tho City, Vietnam, from November 2022 to April 2023. We used real-time polymerase chain reaction (PCR) to detect infectious agents. Patients underwent examinations and tests to assess clinical features and laboratory data. Results: Rotavirus was the most commonly detected agent (42.7%). The incidence of co-infection with other bacterial or viral microorganisms alongside Rotavirus was 45.2%. Acute diarrhea caused by Rotavirus significantly increased the percentage of children with watery stools (P = 0.004) and vomiting (P < 0.001) and led to a greater number of loose stools per day (P = 0.007) compared to cases without Rotavirus. However, there were no significant differences in clinical features or laboratory data between cases with Rotavirus mono-infection and those with co-infections involving other bacterial or viral microorganisms. Conclusions: This study sheds light on the prevalence of Rotavirus and co-infections in Vietnam. Among these findings, identifying Rotavirus in children with acute diarrhea is more critical than detecting co-infecting agents. | en |
| DOI | https://doi.org/10.5812/apid-140509 | en |
| Keyword | <i>Rotavirus</i> | en |
| Keyword | Co-infection | en |
| Keyword | Acute Diarrhea | en |
| Keyword | Children | en |
| Keyword | Real-time PCR | en |
| Publisher | Brieflands | en |
| Title | A Cross-sectional Study on the Role of <i>Rotavirus</i> and Microbial Co-infection in Children with Acute Diarrhea in Vietnam | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- apid-12-1-140509.pdf
- Size:
- 314.1 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF