Investigation of Possible Role of <i>Chlamydia</i> in Pseudoexfoliation Syndrome
| Author | Serpil Gonca | en |
| Author | Mehmet Sami Serin | en |
| Author | Ayça Yılmaz | en |
| Author | Özgün Oktay | en |
| Author | Ayşe Serin | en |
| Author | Zehra Öksüz | en |
| Orcid | Mehmet Sami Serin [0000-0002-5113-5509] | en |
| Issued Date | 2021-05-31 | en |
| Abstract | Background: Pseudoexfoliation syndrome (PES) is a systemic disease characterized by the aggregation of fibrillar extracellular material in intraocular and extraocular tissues with unknown etiology. Clarifying the etiopathogenesis of PES would be important for public health. Objectives: We aimed to investigate the possible role of Chlamydia in the etiology of PES. Methods: This cross-sectional study was carried out in the ophthalmology clinic of a tertiary hospital. The study included two groups, including the patient group (PES patients with nuclear cataracts) and the control group (patients with nuclear cataracts). Patients with other ophthalmic problems and systemic diseases were excluded. Blood samples and conjunctival swabs taken from 49 patients and 42 controls were used in the study. Anti-Chlamydia trachomatis IgG and IgM, anti-C. pneumoniae IgG and IgM, Interleukin (IL)-6, and IL-20 were studied in the serum samples. The PCR study was performed with conjunctival swab samples and sequence analysis of PCR-positive samples was performed. Results: According to the results of the study, there was no statistically significant difference between the groups in terms of anti-C. trachmatis IgG, anti-C. trachmatis IgM, anti-C. pneumoniae IgM, IL-6, and PCR results. There was a statistically significant difference between patient and control groups in terms of anti-C. pneumoniae IgG and IL-20 levels. The DNA sequencing of all PCR products was found to be compatible with C. pneumoniae. Conclusions: It seems that C. pneumoniae might have an important role in the etiology and development of PES. However, further studies in larger groups are needed to clarify these results. | en |
| DOI | https://doi.org/10.5812/jjm.116962 | en |
| Keyword | Pseudoexfoliation Syndrome | en |
| Keyword | <i>Chlamydia</i> | en |
| Keyword | Interleukin-6 | en |
| Keyword | Interleukin-20 | en |
| Publisher | Brieflands | en |
| Title | Investigation of Possible Role of <i>Chlamydia</i> in Pseudoexfoliation Syndrome | en |
| Type | Research Article | en |
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