Changes in Salivary Melatonin Levels by Scaling and Root Planing in Patients with Chronic Periodontitis
| Author | Atefeh Purrahmani | en |
| Author | Negin Soghli | en |
| Author | Durdi Qujeq | en |
| Author | Amir Kiakojori | en |
| Author | Hemmat Gholinia | en |
| Orcid | Negin Soghli [0000-0002-6015-2212] | en |
| Orcid | Durdi Qujeq [0000-0003-1344-9344] | en |
| Orcid | Hemmat Gholinia [0000-0003-0517-2429] | en |
| Issued Date | 2021-06-30 | en |
| Abstract | Background: Periodontitis is a chronic inflammatory disease that causes tissue destruction due to the imbalance in the oxidant-antioxidant system. Melatonin has anti-inflammatory, antioxidant, and immune-modulatory properties and is considered to be a biomarker and diagnostic/therapeutic agent in the pathogenesis of periodontitis. Objectives: The present study aimed to evaluate the salivary melatonin level and its changes following non-surgical periodontal therapy in patients with periodontitis. Methods: In total, 90 salivary samples were collected from 60 patients, including 30 from patients with moderate chronic periodontitis (before periodontal treatment), and 30 from the same patients one month after the non-surgical periodontal therapy, and 30 from periodontally healthy subjects (control). Salivary melatonin levels were measured using the competitive immunoassay of the human melatonin ELISA kit. Results: The highest melatonin concentration was observed in the control group (79.55 ± 59.22; P < 0.05), while the lowest concentration was observed in the pre-treatment group (P < 0.05). In addition, salivary melatonin concentration in the post-treatment group (56.58 ± 46.48) was significantly higher compared to the pre-treatment group (17.25 ± 5.79; P < 0.05). Conclusions: According to the results, salivary melatonin levels improved after non-surgical periodontal therapy, which suggests the involvement of melatonin in the pathogenesis of periodontitis. However, the exact role of melatonin requires further investigation. | en |
| DOI | https://doi.org/10.5812/jkums.113275 | en |
| Keyword | Non-surgical Periodontal Therapy | en |
| Keyword | Melatonin | en |
| Keyword | Chronic Periodontitis | en |
| Keyword | Saliva | en |
| Publisher | Brieflands | en |
| Title | Changes in Salivary Melatonin Levels by Scaling and Root Planing in Patients with Chronic Periodontitis | en |
| Type | Research Article | en |
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