Metformin-Insulin Combination Therapy Ameliorates Hyperglycemia in a COVID-19 Type-1 Diabetic Child with Insulin Resistance: A Case Report

Author	Parisa Tajdini	en
Author	Arezoo Akhlaghi Aski	en
Orcid	Parisa Tajdini [0000-0002-3045-6880]	en
Issued Date	2024-03-31	en
Abstract	Introduction: Recent studies have indicated that COVID-19 may be linked with type 1 diabetes mellitus (T1DM) in children. It has been observed that not only is there a potential risk of new-onset pediatric T1DM associated with COVID-19, but numerous cases also present with insulin resistance, necessitating prompt management. Case Presentation: We report the case of a 9-year-old girl with a history of T1DM who was admitted with hyperglycemia (blood sugar > 750 mg/dL) and subsequently diagnosed with COVID-19. The co-administration of metformin and intravenous insulin successfully resolved subcutaneous insulin resistance, allowing the patient to be discharged in good health. Conclusions: Insulin resistance is a recognized complication of SARS-CoV-2 infection, and metformin combined with intravenous insulin has proven effective in managing hyperglycemia and improving insulin resistance in this context. Further research is necessary to elucidate the underlying mechanisms and develop optimal therapeutic strategies.	en
DOI	https://doi.org/10.5812/jmb-147125	en
Keyword	COVID-19	en
Keyword	Diabetes Mellitus	en
Keyword	Diabetic Ketoacidosis	en
Keyword	Metformin	en
Publisher	Brieflands	en
Title	Metformin-Insulin Combination Therapy Ameliorates Hyperglycemia in a COVID-19 Type-1 Diabetic Child with Insulin Resistance: A Case Report	en
Type	Case Report	en

Files

Now showing 1 - 1 of 1