Combination Therapy with Ceftazidime-Avibactam and Amikacin for Multidrug-Resistant <i>Pseudomonas aeruginosa</i> Infection with Fulminant Myocarditis in a Younger Patient: A Case Report and Literature Review
| Author | Xiuhong Zhang | en |
| Author | Sihui Cai | en |
| Author | Chunyan Chang | en |
| Author | Qiuhui Wang | en |
| Author | Weizhen Qiao | en |
| Orcid | Xiuhong Zhang [0000-0003-0114-202X] | en |
| Orcid | Sihui Cai [0009-0005-6858-502X] | en |
| Orcid | Chunyan Chang [0009-0009-2122-199X] | en |
| Orcid | Qiuhui Wang [0009-0002-2441-9503] | en |
| Orcid | Weizhen Qiao [0000-0001-8000-6143] | en |
| Issued Date | 2023-05-31 | en |
| Abstract | Introduction: Fulminant myocarditis is a life-threatening disease among young patients. Pseudomonas aeruginosa is distributed in nature and is often spread as an opportunistic pathogen to cause hospital-acquired infections in patients with underlying diseases and low immunity. Case Presentation: This report presented a case of a 28-year-old woman with fulminant myocarditis followed by P. aeruginosa infection. After hospitalization, she received veno-arterial extracorporeal membrane oxygenation (ECMO) and continuous renal replacement treatment (CRRT). Initially, piperacillin sodium tazobactam combined with amikacin was used for anti-infection therapy, which had a poor clinical effect. Subsequently, it was recommended to use ceftazidime-avibactam and amikacin for treatment. Finally, the infection index of the patient returned to normal. Conclusions: It is necessary to select correct and effective drugs according to etiology, considering the influence of ECMO and CRRT on the patient’s antimicrobial pharmacokinetics/pharmacodynamics (PK/PD). This case could provide a reference for safe and rational drug use in clinical practice. | en |
| DOI | https://doi.org/10.5812/jjm-136894 | en |
| Keyword | Myocarditis | en |
| Keyword | Multidrug-Resistant | en |
| Keyword | <i>Pseudomonas aeruginosa</i> | en |
| Keyword | ECMO | en |
| Keyword | CRRT | en |
| Publisher | Brieflands | en |
| Title | Combination Therapy with Ceftazidime-Avibactam and Amikacin for Multidrug-Resistant <i>Pseudomonas aeruginosa</i> Infection with Fulminant Myocarditis in a Younger Patient: A Case Report and Literature Review | en |
| Type | Case Report | en |