The Impact of Organized Exercise and Non-organized Leisured Time Activity on Serum Pentraxin3 and C-reactive Protein Levels, Lipid Profile and Physical Fitness in Diabetic Children
| Author | Maryam Nazari | en |
| Author | Vazgen Minasian | en |
| Orcid | Maryam Nazari [0000-0002-3502-872X] | en |
| Orcid | Vazgen Minasian [0000-0002-7404-1409] | en |
| Issued Date | 2024-06-30 | en |
| Abstract | Background: Microvascular changes and precursors of atherosclerosis are frequently observed in young patients with early-onset type 1 diabetes (T1DM). Due to their known beneficial effects, physical activity is strongly recommended for its management. Objectives: This study aimed to investigate the effects of eight weeks of organized exercise (OE) and non-organized leisure time activity (NOLTA) on determinants of cardiovascular disease and physical fitness in children with type 1 diabetes. Methods: In this quasi-experimental study, 20 children with T1DM were randomly divided into two groups of 10: OE (n = 10, mean age = 12.60 ± 1.34 years) and NOLTA (n = 10, mean age = 12.40 ± 0.84 years). Subjects in both groups participated in their respective activities 3 days per week. Blood samples and physiological measurements were taken 48 hours before and after the 8-week training period. Results: High-density lipoprotein (HDL) levels and physical fitness factors increased significantly in both exercise groups. Fasting blood glucose, C-reactive protein, and the cholesterol/HDL ratio were also significantly reduced in both groups. Waist circumference, glycosylated hemoglobin, and the LDL/HDL ratio were significantly reduced only in the OE group. However, the decrease in the acute phase protein pentraxin 3 was minimal and statistically insignificant. Conclusions: In children and adolescents with T1DM, regular exercise—due to its anti-inflammatory effects and its ability to improve cardiorespiratory fitness, lipid profile, and blood glucose levels—may help reduce the severity and likelihood of cardiovascular disease in adulthood. | en |
| DOI | https://doi.org/10.5812/asjsm-147429 | en |
| Keyword | Diabetes Mellitus | en |
| Keyword | Type 1 | en |
| Keyword | C-reactive Protein | en |
| Keyword | Exercises | en |
| Keyword | Pentraxin3 | en |
| Keyword | Inflammation | en |
| Keyword | Lipid Profile | en |
| Publisher | Brieflands | en |
| Title | The Impact of Organized Exercise and Non-organized Leisured Time Activity on Serum Pentraxin3 and C-reactive Protein Levels, Lipid Profile and Physical Fitness in Diabetic Children | en |
| Type | Research Article | en |
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