Designing an Experimental Angiogenesis Model in a Three Dimensional Matrix of Fibrin to Evaluate Neoplastic Growth Inhibitors

Abstract

Introduction: Angiogenesis play an important role in many physiological processes (embryonic growth, tissue repair, etc) and also in pathological ones (diabetes, retinopathy, arthritis, tumor growth, etc). Evaluation of endothelial cell growth and finally new vessel development in vivo is a complex and often difficult task.