Production, Quality Control and Pharmacokinetic Studies of <sup>177</sup>Lu-EDTMP for Human Bone Pain Palliation Therapy Trials
| Author | Ali Bahrami-Samani | en |
| Author | Akbar Anvari | en |
| Author | Amir Reza Jalilian | en |
| Author | Simindokht Shirvani-Arani | en |
| Author | Hassan Yousefnia | en |
| Author | Mahmoud Reza Aghamiri | en |
| Author | Mohammad Ghannadi-Maragheh | en |
| Issued Date | 2012-01-31 | en |
| Abstract | Developing new bone pain palliation agents is a mandate in handling end-stage cancer patients around the world. Possibly, Lu-177 ethylenediaminetetramethylene phosphonic acid (177Lu-EDTMP) is a therapeutic agent which can be widely used in bone palliation therapy. In this study, 177Lu-EDTMP complex was prepared successfully using synthesized EDTMP ligand and 177LuCl3. Lu-177 chloride was obtained by thermal neutron irradiation (4 × 1013 n.cm-2s-1) of natural Lu2O3 samples. Radiochemical purity of 177Lu-EDTMP was determined by ITLC (more than 99%). Stability studies of the final preparations in the presence of human serum were performed. The biodistribution of 177Lu-EDTMP and 177LuCl3 in wild-type rats was studied by SPECT imaging. A comparative accumulation study for 177Lu-EDTMP and 177LuCl3 was performed for vital organs up to 7 days. The complex was obtained in high radiochemical purity (more than 99%). The complex was stable in vitro in presence of human serum as well as final formulation. Significant bone uptake (> 70%) was observed for the radiopharmaceutical. Due to better physical properties of Lu-177 compared to Sm-153 and acceptable biodistribution results of the compound, 177Lu-EDTMP seemed to be an interesting new candidate for clinical trials for bone pain palliation therapy. | en |
| DOI | https://doi.org/10.22037/ijpr.2012.1081 | en |
| Keyword | 177Lu-EDTMP | en |
| Keyword | Radiopharmaceutical | en |
| Keyword | Biodistribution | en |
| Keyword | Pharmacokinetic | en |
| Keyword | Quality control. | en |
| Publisher | Brieflands | en |
| Title | Production, Quality Control and Pharmacokinetic Studies of <sup>177</sup>Lu-EDTMP for Human Bone Pain Palliation Therapy Trials | en |
| Type | Original Article | en |
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