High Levels of Circulating IL-6 and IL-8 Signature Can Predict COVID-19 Severity
| Author | Didem Ozgür | en |
| Author | Murat Karamese | en |
| Author | Alpay Medetalibeyoglu | en |
| Author | Onur Alkan | en |
| Author | Naci Senkal | en |
| Author | Emin Ediz Tutuncu | en |
| Orcid | Didem Ozgür [0000-0002-8320-9453] | en |
| Orcid | Murat Karamese [0000-0001-7803-1462] | en |
| Orcid | Alpay Medetalibeyoglu [0000-0001-6828-4378] | en |
| Orcid | Onur Alkan [0000-0002-8558-1654] | en |
| Orcid | Naci Senkal [0000-0001-7072-8724] | en |
| Orcid | Emin Ediz Tutuncu [0000-0002-7583-8081] | en |
| Issued Date | 2021-10-31 | en |
| Abstract | Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may trigger a cytokine storm, which is characterized by uncontrolled overproduction of proinflammatory cytokines. Objectives: We aimed to investigate the association between circulating levels of inflammatory cytokines and severity of coronavirus disease 2019 (COVID-19). Methods: This cross-sectional study included 46 severe and 32 mildly symptomatic COVID-19 patients. The serum levels of cytokines and chemokines were determined using the Bio-Plex ProTM Human Cytokine Screening Panel. Results: Out of a total of 78 patients with confirmed COVID-19, 54 (69.2%) were males, and 24 (30.8%) were females. The mean age was 43.1 ± 13.3 and 58.2 ± 15 in mild and severe patients, respectively. Severe patients were characterized by significant laboratory abnormalities, such as increased WBC (P = 0.002) and neutrophil counts (P = 0.001), higher levels of ALT (P = 0.03), AST (P = 0.002), LDH (P < 0.001), urea (P = 0.013), ferritin (P < 0.001), D-dimer (P = 0.042), CRP (P < 0.001), and decreased lymphocyte (P < 0.001) and platelet (P = 0.045) counts. The levels of IL-6, IL-8, IL-13, TNF-α, IFN-γ, MIP-1β, and MCP-1 increased in the severe group compared to the mild group. However, significant differences were observed only for IL-6 (P < 0.001) and IL-8 (P < 0.001) levels. Conclusions: Serum IL-6 and IL-8 levels can be used as potential prognostic biomarkers of disease severity in COVID-19 patients. | en |
| DOI | https://doi.org/10.5812/jjm.119060 | en |
| Keyword | SARS-CoV-2 | en |
| Keyword | COVID-19 | en |
| Keyword | Cytokine Storm | en |
| Keyword | Proinflammatory Cytokines | en |
| Keyword | Interleukin-6 | en |
| Keyword | Interleukin-8 | en |
| Publisher | Brieflands | en |
| Title | High Levels of Circulating IL-6 and IL-8 Signature Can Predict COVID-19 Severity | en |
| Type | Research Article | en |
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