Human Cytomegalovirus in Oral Squamous Cell Carcinoma in Southeast of Iran

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AuthorShirin Saravanien
AuthorHamideh Kadehen
AuthorEbrahim Miri-Moghaddamen
AuthorAli Zekrien
AuthorNima Sanadgolen
AuthorAliye Gholamien
Issued Date2015-08-01en
AbstractBackground: Carcinogenesis is a multi-step process and the role of infectious agents in this progression has not been fully identified. Since human cytomegalovirus (HCMV) is frequently presented in the gingival sulcus fluid, we hypothesized that this virus would be important in the pathogenesis of oral squamous cell carcinoma (OSCC). Objectives: The aim of this study was to investigate the presence of active HCMV in different histopathological grades of OSCC in southeast of Iran. Materials and Methods: Forty eight individual specimens were evaluated in this study. Serial sections were obtained from paraffin-embedded tissue samples of OSCC biopsies. The frequency of HCMV was investigated using the real-time polymerase change reaction method after DNA extraction from biopsies. Results: The mean age of the patients (66.7% female and 33.3% male) was 58.6 years. Only three cases (6.3%) of the grade I, OSCC biopsies, were positive for active HCMV with average load of 57.7 × 103. Conclusions: According to the low prevalence of HCMV in OSCC, it seems that this virus plays a minor role in this kind of cancer at least in southeast of Iran. More comprehensive studies are needed to investigate the oncomodulatory effect of this virus on OSCC.en
DOIhttps://doi.org/10.5812/jjm.21838en
KeywordHumanen
KeywordCytomegalovirusen
KeywordSquamous Cell Carcinomaen
KeywordCanceren
PublisherBrieflandsen
TitleHuman Cytomegalovirus in Oral Squamous Cell Carcinoma in Southeast of Iranen
TypeBrief Reporten

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