The Effect of Treating Vitamin D Deficiency or Insufficiency on Serum Adiponectin, Leptin and Insulin Resistance of Type 2 Diabetes Mellitus Patients: A Pilot Study
| Author | Afshin Gharekhani | en |
| Author | Farzad Najafipour | en |
| Author | Hananeh Baradaran | en |
| Author | Parisa Tagharrobi | en |
| Author | Haleh Rezaee | en |
| Issued Date | 2020-07-31 | en |
| Abstract | Vitamin D deficiency is considered as one of the most prevalent healthcare problems in the world. Vitamin D contributes to insulin synthesis and secretion. Deficiency of vitamin D leads to insulin resistance which is the major cause of type 2 diabetes mellitus. We aim to evaluate the effect of treating vitamin D deficiency or insufficiency on serum adiponectin, leptin, and leptin to adiponectin ratio (LAR) of type 2 diabetes mellitus patients. Forty patients with type 2 diabetes mellitus were included according to the inclusion criteria of the study. Fasting venous blood samples were obtained and evaluated before and after the treatment of vitamin D deficiency or insufficiency. Then, blood levels of leptin, adiponectin, and LAR (an indicator of insulin resistance) were measured. The results of study indicate a significant decline in circulating leptin and adiponectin after vitamin D treatment, but it doesn’t cause a noteworthy change in LAR. Furthermore, the study demonstrates that female gender, higher body mass index, and triglyceride levels increase LAR significantly. It was concluded that the treatment of vitamin D deficiency or insufficiency doesn’t change insulin resistance in diabetic patients. Moreover, we concluded that LAR is not a reliable method to compare insulin resistance between men and women due to sex-related differences in adipose tissue. | en |
| DOI | https://doi.org/10.22037/ijpr.2020.112067.13512 | en |
| Keyword | Adiponectin | en |
| Keyword | Insulin resistance | en |
| Keyword | Leptin | en |
| Keyword | Type 2 diabetes mellitus | en |
| Keyword | Vitamin D | en |
| Publisher | Brieflands | en |
| Title | The Effect of Treating Vitamin D Deficiency or Insufficiency on Serum Adiponectin, Leptin and Insulin Resistance of Type 2 Diabetes Mellitus Patients: A Pilot Study | en |
| Type | Original Article | en |
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