Effects of Soy Protein Isoflavones on Serum Lipids, Lipoprotein Profile and Serum Glucose of Hypercholesterolemic Rabbits
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Abstract
The main objective of this research was to determine the effects of soy protein isoflavones on serum lipids, lipoproteins and fasting blood sugar levels in hypercholesterolemic rabbits_ Materials and Method: Twenty-four male New Zealand rabbits received the basic pellet diet for two weeks and were then placed on a hypercholesterolemic diet (pellets plus 1% cholesterol) for three weeks. Mter elevation of total cholesterol, the rabbits were randomly allocated into four experimental groups. Groups 1 to 3 received loog soy protein containing 200mg (SPI+), lOOmg (SPI50%) soy protein diet and without isoflavones (SPI-), respectively, for six weeks. The fourth group was kept on the hypercholesterolemic diet (HC).Results: Findings showed that cholesterol rich diet produced significant increase in total, LDLand HDL-cholesterol concentrations. In SPI+ group these parameters remained unchanged, compared with SPI-and SPI50% groups (P