Association of serum cortisol with critical illness scoring and prognosis in intensive care unit
| Author | S Hashemi pour | en |
| Author | F Azizi | en |
| Author | B Mehrtash | en |
| Author | N Mohammadi | en |
| Author | M Sarreshtehdari | en |
| Author | MR Sarokhani | en |
| Issued Date | 2012-09-30 | en |
| Abstract | Background: The prevalence of adrenal insufficiency and association of serum cortisol with prognosis in intensive care unit patients is controversial. Some studies have shown a direct association between serum cortisol and bad prognosis while in other studies no such association has been made. Objective: This study was designed to evaluate the association between serum cortisol and prognosis of patients in intensive care unit. Methods: This was a cross-sectional study performed on intensive care unit patients of Bou-Ali teaching hospital in Qazvin (Iran) in 2009. Serum cortisol levels were measured before and after injection of cosyntropin. Basal cortisol level below 441 nmol/l was interpreted as adrenal insufficiency. In patients with serum cortisol between 441 and 938 nmol/l following injection of cosyntropin the level of serum cortisol was re-measured after 60 min. Patients with serum cortisol response less than 255 nmol/l were interpreted as having partial adrenal insufficiency. Later, patients were divided into 4 groups based on APACHE scoring system. Association of serum cortisol with APACHE score, hypotension, intubation, and mortality was evaluated. Findings: Of 60 patients under study, none found to have adrenal insufficiency. Serum cortisol was independently associated with mortality, hypotension, and intubation. Conclusion: Based on results found through this study, Adrenal insufficiency was not common in ICU patients and serum cortisol could be used as a predictor of prognosis. | en |
| DOI | https://doi.org/ | en |
| Keyword | Adrenal Insufficiency | en |
| Keyword | Cortisol | en |
| Keyword | Intensive Care Unit | en |
| Keyword | Prognosis | en |
| Publisher | Brieflands | en |
| Title | Association of serum cortisol with critical illness scoring and prognosis in intensive care unit | en |
| Type | Research Article | en |
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