Dual COX-2/TNF-α Inhibitors as Promising Anti-inflammatory and Cancer Chemopreventive Agents: A Review
| Author | Mobina Tajdari | en |
| Author | Amirreza Peyrovinasab | en |
| Author | Maryam Bayanati | en |
| Author | Mohammad Ismail Mahboubi Rabbani | en |
| Author | Amir Hossein Abdolghaffari | en |
| Author | Afshin Zarghi | en |
| Orcid | Mobina Tajdari [0009-0005-0801-1761] | en |
| Orcid | Amirreza Peyrovinasab [0009-0004-6100-3667] | en |
| Orcid | Afshin Zarghi [0000-0002-6470-7895] | en |
| Issued Date | 2024-12-31 | en |
| Abstract | Cyclooxygenases (COX) play a pivotal role in inflammation and are responsible for the production of prostaglandins (PGs). Two types of COXs have been identified as key biological targets for drug design: Constitutive COX-1 and inducible COX-2. Nonsteroidal anti-inflammatory drugs (NSAIDs) target COX-1, while selective COX-2 inhibitors are designed for COX-2. These COX isoforms are involved in multiple physiological and pathological pathways throughout the body. Overproduction of tumor necrosis factor-alpha (TNF-α) plays a role in COX-2's inflammatory activity. Tumor necrosis factor-alpha can contribute to cardiac fibrosis, heart failure, and various cancers by upregulating the COX-2/PGE2 axis. Therefore, suppressing COX activity has emerged as a potentially effective treatment for chronic inflammatory disorders and cancer. This review explores the mechanisms of TNF-α-induced COX-2/PGE2 expression, a significant pathophysiological feature of cancer development. Furthermore, we summarize chemical compounds with dual COX-2/TNF-α inhibitory actions, providing an overview of their structure-activity relationship. These insights may contribute to the development of new generations of dual-acting COX-2/TNF-α inhibitors with enhanced efficacy. | en |
| DOI | https://doi.org/10.5812/ijpr-151312 | en |
| Keyword | COX-2 | en |
| Keyword | TNF-α | en |
| Keyword | Dual Inhibitors | en |
| Keyword | Cancer | en |
| Publisher | Brieflands | en |
| Title | Dual COX-2/TNF-α Inhibitors as Promising Anti-inflammatory and Cancer Chemopreventive Agents: A Review | en |
| Type | Review Article | en |