Neurotransmitter Inhibitors as Therapeutic Targets: Their Role in Growth, Migration, Angiogenesis, and Metastasis of Breast Cancer

Abstract

Context: Breast cancer is a lethal multifactorial illness among women. Recent studies have highlighted the importance of the neural network in breast tumor progression. Objectives: This review aimed to consider the potential contributions of neurotransmitters to breast cancer growth, migration, angiogenesis, and metastasis, as well as to discuss the function of neurotransmitter inhibitors in preventing tumor growth. Results: Neurons infiltrate the tumor microenvironment by secreting neurotransmitters and actively stimulate tumor progression. In breast cancer cells, neurotransmitters induce migration, growth, angiogenesis, and metastasis by regulating intracellular signaling pathways downstream of neurotransmitter receptors. Neurotransmitter inhibitors may therefore represent an alternative approach for breast cancer management. Conclusions: Neurotransmitter inhibitors might be crucial for targeting breast cancer treatment.