Determination of peroxisome proliferator-activated receptor-gamma polymorphism in patients with helicobacter pylori infection
| Author | Hossein Godarzi | en |
| Author | Sima Sadat SeyedJavadi | en |
| Author | Mehdi Goudarzi | en |
| Issued Date | 2012-03-31 | en |
| Abstract | Introduction: Peroxisome proliferator-activated receptor gamma (PPAR g ) is a ligand-dependent transcription factor involved in various disease processes including inflammation and carcinogenesis .This study aimed to determine polymorphism of PPAR g gene and its association with Helicobacter pylori infection and gastrointestinal diseases in patients. Materials and Methods: Two hundred patients with helicobacter pylori infection were examined. H. pylori infection was diagnosed by histology, rapid urease test (RUT), culture, ELISA and PCR. PPAR g polymorphism was analyzed by PCR-based restriction fragment length polymorphism. Results : In total 200 patients (4 gastric cancer, 141gastritis, 35 peptic ulcer, 18 duodenal ulcer, 2 peptic ulcer and duodenal ulcer) with Helicobacter pylori infection were enrolled .The frequency of PPAR g G (Ala12) allele (5%) showed a significant association with gastric cancer (P=0.004) or gastritis (P=0.007). PPAR g GC (Pro12Ala) allele (35%) showed a significant association with duodenal ulcer (P=0.03) or gastritis (P=0.002). Conclusion : Pro12Ala PPAR g polymorphism is associated with gastric cancer and gastritis and is a potential marker for genetic susceptibility to these two diseases in the presence of H. pylori infection. Finally, our study suggests the potential association between PPAR g polymorphism and H. pylori infection in the development of gastric cancer and peptic ulcer and gastritis. | en |
| DOI | https://doi.org/ | en |
| URI | https://brieflands.com/journals/koomesh/articles/152503 | en |
| Keyword | Helicobacter pylori, PPAR gene polymorphism,Gastric cancer | en |
| Keyword | هلیکوباکتر پیلوری، پلیمورفیسم ژن PPAR-، سرطان معده | en |
| Publisher | Brieflands | en |
| Title | Determination of peroxisome proliferator-activated receptor-gamma polymorphism in patients with helicobacter pylori infection | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- article-1-1138-fa.pdf.pdf
- Size:
- 301.4 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF