Impact of Apo Lipoprotein E Gene Polymorphism on Hepatitis C Virus Disease Progression and Response to Direct Acting Antivirals in the Egyptian Population
| Author | Monkez M Yousif | en |
| Author | Fayrouz Othman Selim | en |
| Author | Ayaat Mohamed Zedan | en |
| Author | Ghada Mohamed Samir | en |
| Author | Ahmed Elsadek Fakhr | en |
| Issued Date | 2020-06-30 | en |
| Abstract | Background: Hepatitis C virus infection is a major health problem in Egypt. Apo lipoprotein E and lipid metabolism are closely associated with the life cycle of the virus and play an important role in facilitating this infection. Objectives: To identify the role of apolipoprotein E gene polymorphism on hepatitis C virus disease progression and response to direct-acting antivirals (DAAs). Methods: We included twenty patients with chronic hepatitis C virus infection (CHC) from those who failed to respond to DAAs treatment and 76 subjects from responders. Apo lipoprotein E genotypes were determined using PCR restriction enzyme fragment length polymorphism (RFLP). Results: Apolipoprotein genotype E3/E3 was prevalent in 75.9% of patients. The distribution for the rest of genotypes was 16.9%, 3.6%, 2.4% and 1.2 % for Apo E3/E4, E2/E3, E4/E4, and E2/E2 respectively. No statistically significant difference was found regarding any of the Apo E genotypes with liver cirrhosis or response to therapy. Conclusions: No significant impact for any Apo E genotypes on CHC disease severity or response to therapy with direct-acting antivirals was detected among Egyptian patients. | en |
| DOI | https://doi.org/10.5812/hepatmon.101516 | en |
| Keyword | Liver Cirrhosis | en |
| Keyword | Gene | en |
| Keyword | Hepatitis C Virus | en |
| Keyword | Polymorphism | en |
| Keyword | Apolipoprotein | en |
| Keyword | Direct-Acting Antivirals | en |
| Publisher | Brieflands | en |
| Title | Impact of Apo Lipoprotein E Gene Polymorphism on Hepatitis C Virus Disease Progression and Response to Direct Acting Antivirals in the Egyptian Population | en |
| Type | Brief Report | en |
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