Elevated Serum Syndecan-1 Levels Are Associated with Obesity-Related Complications in Children
| Author | Meltem Erol | en |
| Author | Aslıhan Tenekecigil | en |
| Author | Abdulrahman Ozel | en |
| Author | Ozlem Bostan Gayret | en |
| Author | Okan Yuce | en |
| Author | Canan Yılmaz | en |
| Orcid | Meltem Erol [0000-0002-7672-1854] | en |
| Orcid | Aslıhan Tenekecigil [0000-0002-3893-7136] | en |
| Orcid | Abdulrahman Ozel [0000-0001-8947-420X] | en |
| Orcid | Ozlem Bostan Gayret [0000-0003-4121-8009] | en |
| Orcid | Okan Yuce [0000-0001-6043-1062] | en |
| Orcid | Canan Yılmaz [0000-0002-6799-6522] | en |
| Issued Date | 2025-02-28 | en |
| Abstract | Background: Syndecan-1 plays a crucial role in cell differentiation, growth, adhesion, wound healing, and inflammatory processes. It has been linked to obesity, particularly overweight and chronic low-grade inflammation. Objectives: This study aimed to compare serum syndecan-1 levels between obese children and a healthy control group and to investigate the relationship between serum syndecan-1 levels and renal and cardiovascular complications associated with obesity in children. Methods: We assessed 30 obese and 30 healthy children aged 8 - 16 years. Blood samples were collected from both groups to measure serum aspartate aminotransferase (AST), syndecan-1, fasting blood glucose (FBG), alanine aminotransferase (ALT), creatinine, and urea concentrations. In the obese group, high-density lipoprotein cholesterol (HDL-C), insulin, triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels were also measured, along with homeostasis model assessment of insulin resistance (HOMA-IR). Results: The mean serum syndecan-1 levels in the obese and control groups were 15.65 ± 10.01 ng/mL and 6.99 ± 3.79 ng/mL, respectively, with a significantly higher level observed in the obese group (P < 0.005). Significant differences were also found in BMI, BMI SDS, creatinine, AST, and ALT levels between the two groups (P < 0.05), with all parameters being higher in the obese group. A significant positive linear association was identified between syndecan-1 levels and creatinine, TG, and BMI SDS (r = 0.711, r = 0.630, r = 0.682, P < 0.01). Additionally, a strong negative correlation was found between syndecan-1 and HDL-C levels (r = -0.609, P < 0.001). No significant linear relationship was detected between syndecan-1 levels and LDL-C, ALT, AST, glucose, urea, insulin levels, or HOMA-IR measurements (P > 0.05). Linear regression analysis revealed that serum creatinine levels and BMI SDS were significantly linked to changes in syndecan-1 levels. Conclusions: Syndecan-1 is elevated in obese children due to inflammation and may serve as an early biomarker for endothelial damage. It can be useful in detecting obesity-related renal damage and cardiovascular risk in children. | en |
| DOI | https://doi.org/10.5812/ijp-148999 | en |
| Keyword | Syndecan 1 | en |
| Keyword | Obesity | en |
| Keyword | Children | en |
| Publisher | Brieflands | en |
| Title | Elevated Serum Syndecan-1 Levels Are Associated with Obesity-Related Complications in Children | en |
| Type | Research Article | en |
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