Existence of Inhibin ?-Subunit Gene Mutation in a Population of Iranian Women with Premature Ovarian Failure
| Author | M Fallahian | en |
| Author | F Pouresmaeili | en |
| Author | F Azizi | en |
| Author | M R Zali | en |
| Author | E M Samani | en |
| Author | P Kharaziha | en |
| Issued Date | 2009-04-30 | en |
| Abstract | Premature ovarian failure (POF) is characterized by hypergonadotropic amenorrhea, before the age of 40, for which the Inhibin α-subunit (INHα) gene is proposed as a candidate gene, due to its role in negative feedback control of FSH. In this study we aimed at demonstrating the candidate mutation as a gene variation associated with POF in Iranian population. Materials & Methods: Using DNA sequencing, DNA samples of 24 women with POF and 24 controls, aged below 40 years, were screened for mutations in the Inhibin gene. Results: The 769G→A mutation in exon 2 of the Inhibin-α gene was found in four out of 24 idi-opathic POF patients. Conclusion: The results obtained in this study have shown that this variation is more frequent in patients with POF than in normal fertile pop-ulations of Iran. | en |
| DOI | https://doi.org/ | en |
| URI | https://brieflands.com/journals/ijem/articles/71721 | en |
| Keyword | Inhibin ?-subunit gene | en |
| Keyword | Premature ovarian failure | en |
| Keyword | Mutation | en |
| Publisher | Brieflands | en |
| Title | Existence of Inhibin ?-Subunit Gene Mutation in a Population of Iranian Women with Premature Ovarian Failure | en |
| Type | Research Article | en |
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