Prevalence of DNA Mismatch Repair Deficiency in Endometrial Cancer Using Immunohistochemistry
| Author | Behnoush Mehdizadeh | en |
| Author | Masoumeh Gharib | en |
| Author | Amir Hossein Jafarian | en |
| Author | Monavvar Afzalaghaee | en |
| Author | Fateme Homaee Shandiz | en |
| Author | Amirhosein Irajpour | en |
| Orcid | Behnoush Mehdizadeh [0000-0003-2501-2684] | en |
| Orcid | Masoumeh Gharib [0000-0003-2501-2684] | en |
| Orcid | Amir Hossein Jafarian [0000-0002-6488-1519] | en |
| Orcid | Monavvar Afzalaghaee [0000-0003-2029-6577] | en |
| Orcid | Fateme Homaee Shandiz [0000-0002-7718-5387] | en |
| Orcid | Amirhosein Irajpour [0000-0001-8265-8268] | en |
| Issued Date | 2022-08-31 | en |
| Abstract | Background: Endometrial cancer (EC) is known as the most common malignancy of the female reproductive system, suggested to be associated with hereditary nonpolyposis colorectal cancer (HNPCC) or Lynch syndrome (LS). Objectives: Therefore, the aim of the present study was to screen for LS in patients with EC using immunohistochemistry (IHC). Methods: In this retrospective cross-sectional study, the patients with EC, referred to Qaem Hospital, Mashhad, Iran, from 2015 - 2019, were enrolled. Paraffin-embedded tissue blocks were then examined via IHC for the expression of four mismatch repair (MMR) proteins, including MLH1, MSH2, MSH6, and PMS2. The demographic and tumor-related data were also extracted from medical records and pathology reports. The data were consequently analyzed at the significance level of P < 0.05. Results: A total number of 100 patients with EC were evaluated using IHC, and 12 (12%) cases were found suspected. As well, no significant relationship was observed between LS and age, tumor site, tumor histology, tumor size, tumor grade, tumor-infiltrating lymphocytes (TILs), and a family/personal history of malignancies. Conclusions: The prevalence of LS based on the IHC expression of the MMR proteins (MLH1, MSH2, MSH6, and PMS2) was 12% in the patients with EC. There was also no significant relationship between the cases suspected and the demographic and tumor-related data. | en |
| DOI | https://doi.org/10.5812/ijcm-119065 | en |
| URI | https://brieflands.com/journals/ijcm/articles/119065 | en |
| Keyword | Lynch Syndrome | en |
| Keyword | Endometrial Cancer | en |
| Keyword | Immunohistochemistry | en |
| Publisher | Brieflands | en |
| Title | Prevalence of DNA Mismatch Repair Deficiency in Endometrial Cancer Using Immunohistochemistry | en |
| Type | Research Article | en |