Effect of Maximal Versus Supra-Maximal Exhausting Race on Lipid Peroxidation, Antioxidant Activity and Muscle-Damage Biomarkers in Long-Distance and Middle-Distance Runners
| Author | Said Mohamed | en |
| Author | Ncir Lamya | en |
| Author | Mansour Hamda | en |
| Issued Date | 2016-03-01 | en |
| Abstract | Background: Exhausting physical exercise increases lipid peroxidation and causes important muscle damages. The human body tries to mitigate these adverse effects by mobilizing its antioxidant defenses. Objectives: This study aims to investigate the effect of a maximal versus supra-maximal race sustained until exhaustion on lipid peroxidation, antioxidant activity and muscle-damage biomarkers in trained (i.e. long-distance and middle-distance runners) and sedentary subjects. Materials and Methods: The study has been carried out on 8 middle-distance runners (MDR), 9 long-distance runners (LDR), and 8 sedentary subjects (SS). Each subject has undergone two exhaustive running tests, the first one is an incremental event (VAMEVAL test), the second one is a constant supra-maximal intensity test (limited-time test). Blood samples were collected at rest and immediately after each test. Results: A significant increase in malondialdehyde (MDA) concentrations was observed in SS and MDR after the VAMEVAL test and in LDR after the Limited-Time test. A significant difference was also observed between LDR and the other two groups after the VAMEVAL test, and between LDR and MDR after the Limited-Time test. Significant modifications, notably, in myoglobin, CK, LDH, IL-6, TNF-α, and TAS were likewise noted but depending on the race-type and the sportive specialty. Conclusions: Maximal and supra-maximal races induce a significant increase in lipid peroxidation and cause non-negligible inflammation and muscle damage. These effects were relatively related to the physical exercise type and the sportive specialty. | en |
| DOI | https://doi.org/10.5812/asjsm.27902 | en |
| Keyword | Lipid Peroxidation | en |
| Keyword | Race | en |
| Keyword | Exhaustion | en |
| Keyword | Malondialdehyde | en |
| Keyword | Inflammation | en |
| Keyword | Muscle Damage | en |
| Keyword | Runners | en |
| Publisher | Brieflands | en |
| Title | Effect of Maximal Versus Supra-Maximal Exhausting Race on Lipid Peroxidation, Antioxidant Activity and Muscle-Damage Biomarkers in Long-Distance and Middle-Distance Runners | en |
| Type | Research Article | en |
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