Adsorptive Behavior and Voltammetric Determination of Hydralazine Hydrochloride at A Glassy Carbon Electrode Modified with Multiwalled Carbon Nanotubes
| Author | Mehdi Khodadadian | en |
| Author | Ronak Jalili | en |
| Author | Mohammad Taher Bahrami | en |
| Author | Gholamreza Bahrami | en |
| Issued Date | 2017-10-31 | en |
| Abstract | An electroanalytical method has been introduced for highly sensitive determination of hydralazine hydrochloride (Hy-HCl) based on its oxidation at a glassy carbon electrode modified with multiwalled carbon nanotubes (MWCNT/GCE). Studies showed that the electrochemical oxidation of Hy-HCl was accompanied by adsorption and highly sensitive responses could be achieved by adsorptive stripping voltammetry. The electrooxidation of Hy-HCl at MWCNT/GCE occurred at ~32 mV which was lower than that observed at bare GCE (~52 mV). The optimum working conditions for determination of the drug using differential-pulse adsorptive stripping voltammetry (DPAdSV) were established. The method exhibited linear responses to Hy-HCl in the concentration range 10-220 nM with a detection limit of 2.7 nM. The proposed method was successfully applied to the determination of this compound in pharmaceutical dosage forms. | en |
| DOI | https://doi.org/10.22037/ijpr.2017.2134 | en |
| Keyword | Carbon nanotube | en |
| Keyword | Hydralazine | en |
| Keyword | Modified electrode | en |
| Keyword | Adsorption | en |
| Keyword | Stripping voltammetry | en |
| Publisher | Brieflands | en |
| Title | Adsorptive Behavior and Voltammetric Determination of Hydralazine Hydrochloride at A Glassy Carbon Electrode Modified with Multiwalled Carbon Nanotubes | en |
| Type | Original Article | en |
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