Immunotherapy in Multiple Myeloma Using Cancer-Testis Antigens
| Author | Soudeh Ghafouri-Fard | en |
| Author | Mahnaz Seifi-Alan | en |
| Author | Roshanak Shamsi | en |
| Author | Ali Esfandiary | en |
| Orcid | Soudeh Ghafouri-Fard [0000-0002-0223-499X] | en |
| Issued Date | 2015-10-28 | en |
| Abstract | Context:: Multiple myeloma (MM) is a B-cell malignancy characterized by monoclonal expansion of abnormal plasma cells in the bone marrow. It accounts for 10% of hematological malignancies. Although patients respond to a wide range of anticancer modalities, relapse occurs in a significant number of the cases. Immunotherapeutic approaches have been evolved to tackle this problem. Cancer-testis antigens CTAs as a group of tumor-associated antigens are appropriate targets for cancer immunotherapy as they have restricted expression pattern in normal tissues except for testis which is an immune-privileged site. Expression of these antigens has been assessed in different malignancies including MM. Evidence Acquisition:: We performed a computerized search of the MEDLINE/PubMed databases with key words: multiple myeloma, cancer-testis antigen, and cancer stem cell and immunotherapy. Results:: Several CTAs including NY-ESO-1, MAGE and GAGE family have been shown to be expressed in MM patients. Cellular and humoral immune responses against these antigens have been detected in MM patients. Conclusions:: The frequent and high expression level of CTAs in MM patients shows that these antigens can be applied as cancer biomarkers as well as targets for immunotherapy in these patients. | en |
| DOI | https://doi.org/10.17795/ijcp-3755 | en |
| Keyword | Multiple Myeloma | en |
| Keyword | Immunotherapy | en |
| Keyword | Cancer-Testis Antigen | en |
| Keyword | Cancer Stem Cell | en |
| Publisher | Brieflands | en |
| Title | Immunotherapy in Multiple Myeloma Using Cancer-Testis Antigens | en |
| Type | Review Article | en |
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