Serum Fetuin-A and Adipsin Levels in Type II Diabetes Patients
| Author | Mansour Karajibani | en |
| Author | Farzaneh Montazerifar | en |
| Author | Mohammad Bagher Sadeghi | en |
| Author | Mahmoud Ali Keikhaie | en |
| Author | Alireza Dashipour | en |
| Orcid | Mansour Karajibani [0000-0002-9032-9330] | en |
| Orcid | Farzaneh Montazerifar [0000-0001-5065-5724] | en |
| Orcid | Mahmoud Ali Keikhaie [0000-0003-2994-4243] | en |
| Orcid | Alireza Dashipour [0000-0002-4024-0012] | en |
| Issued Date | 2019-09-30 | en |
| Abstract | Background: Fetuin-A is a glycoprotein known as a biomarker for diabetes risk. Adipsin or complement factor D (CFD) plays a role in glucose tolerance, and metabolism. Objectives: This study aimed to investigate the concentration of fetuin-A and adipsin in patients with type 2 diabetes mellitus (T2DM) and healthy subjects. Patients and Methods:: This case–control study was carried out on 43 patients with T2DM and 41 healthy subjects. Biochemical parameters were determined. Fetuin-A and adipsin levels were measured using ELISA kits. Lipid profile and biochemical factors were measured by spectrophotometric methods. Results: The results showed a trend toward lower fetuin-A and CFD concentrations between the two groups (P < 0.05). There was a significant correlation between the levels of fetuin- A and adipsin (P < 0.0001), FBS and HbA1C (P = 0.02), FBS and creatinine (P = 0.03), and BUN (P < 0.001).There was significant differences according to biochemical levels between the two groups (P < 0.001). Conclusions: The findings suggest that fetuin-A and adipsin levels were decreased in T2DM. It seems that the result of fetuin-A and adipsin levels in the diabetes depends on numerous vague factors. Nevertheless, in comparison with published data the changes of fetuin and adipsin levels in patients with T2DM indicate a complex but not complete role of fetuin-A and adipsin in the pathogenesis of T2DM. | en |
| DOI | https://doi.org/10.5812/ijhrba.91963 | en |
| Keyword | Fetuins | en |
| Keyword | Complement Factor D | en |
| Keyword | Human | en |
| Keyword | Biomarkers | en |
| Keyword | Diabetes Mellitus | en |
| Keyword | Type 2 (T2DM) | en |
| Publisher | Brieflands | en |
| Title | Serum Fetuin-A and Adipsin Levels in Type II Diabetes Patients | en |
| Type | Research Article | en |
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