Genetic Polymorphism of Thr241Met and Other Risk Factors Related with Gastric Cancer in Iranian Military Population: A Pilot Case Control Study
| Author | Hassan Khanzadeh | en |
| Author | Ali Reza Khoshdel | en |
| Author | Shahrokh Irvani | en |
| Author | Keivan Majidzadeh-A | en |
| Author | Mohammad Soleimani | en |
| Orcid | Mohammad Soleimani [0000-0002-8270-9499] | en |
| Issued Date | 2019-06-12 | en |
| Abstract | Background: Gastric cancer (GC) is a result of interaction between genetic and environmental factors. The recognition of GC risk factors is very important for early diagnostic and prevention from this cancer. Objectives: The objective of this study was to investigate the effects of some factors such as Thr241Met polymorphism on GC occurrence in Iranian military population. Methods: Investigated samples in the present study were 53 tissue samples from patients with pathologically proven GC and 91 sex-age matched blood samples from healthy controls. Data for cases and controls were obtained through registered files and questionnaires, respectively. Genomic DNA was extracted and PCR-RFLP was used for genotyping of Thr241Met polymorphism. Chi-square and odds ratio (OR) were used to determine the factors affecting the incidence of GC. Results: The Thr\Met genotype of Thr241Met polymorphism of the XRCC3 gene (P = 0.04 and OR = 2.99) and blood type B (P = 0.04 and OR = 2.99) significantly affected the incidence of GC. This study did not prove the significant effect of smoking (P = 0.08 and OR = 2.47) and positive family history (P = 0.13 and OR = 2.25) on GC risk. Conclusions: These findings may be helpful in early identification of high-risk individuals, especially in military population and prevention from GC. | en |
| DOI | https://doi.org/10.5812/jamm.92673 | en |
| Keyword | Gastric Cancer | en |
| Keyword | Risk Factor | en |
| Keyword | Genetic Marker | en |
| Keyword | PCR RFLP | en |
| Keyword | Thr241Met. | en |
| Publisher | Brieflands | en |
| Title | Genetic Polymorphism of Thr241Met and Other Risk Factors Related with Gastric Cancer in Iranian Military Population: A Pilot Case Control Study | en |
| Type | Research Article | en |
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