Serum Omentin-1 Levels in Obese Adolescents with Vitamin D Deficiency: A Prospective Cross-sectional Study
| Author | Meltem Erol | en |
| Author | Fatih Karan | en |
| Author | Abdulrahman Ozel | en |
| Author | Ozlem Bostan Gayret | en |
| Author | Oguzhan Zengi | en |
| Orcid | Meltem Erol [0000-0002-7672-1854] | en |
| Orcid | Fatih Karan [0000-0001-9248-1152] | en |
| Orcid | Abdulrahman Ozel [0000-0001-8947-420X] | en |
| Orcid | Ozlem Bostan Gayret [0000-0003-4121-8009] | en |
| Orcid | Oguzhan Zengi [0000-0002-4614-5235] | en |
| Issued Date | 2023-10-31 | en |
| Abstract | Background: Vitamin D deficiency is common in obese adolescents. It modulates the release of omentin 1 from adipose tissue. We believe that both vitamin D and omentin 1 affect each other in adipose tissue via inflammation. Objectives: This study aimed to examine serum omentin-1 levels in obese adolescents with vitamin D (Vit D) deficiency. Methods: In this cross-sectional prospective study, 83 obese adolescents were included. Serum 25-hydroxy vitamin D (25(OH)D) concentrations, fasting glucose, and lipid profiles of obese adolescents were studied. At the same time, blood was drawn into a separate tube to study the omentin 1 level. Of the 83 obese cases, 45 with 25(OH)D concentrations below 20 ng/mL were considered as the study group, and 38 with 25(OH)D concentrations ≥ 20 ng/mL as the control group. Serum omentin-1 levels were evaluated and compared. Results: The average 25(OH)D value in the study and control groups was 17.14 ± 2.22 ng/mL and 45.29 ± 24.98 ng/mL, respectively. The average omentin-1 concentration of the control group was 262.5 ± 136.31 ng/mL, and the mean omentin-1 level of the study group was 113.23 ± 15.98 ng/mL. The mean omentin-1 concentrations of the study group were significantly lower compared to the control group (P = 0.0001). There was a significant and positive correlation between omentin-1 and 25(OH)D (r = 0.988, P = 0.0001). In univariate tests, linear regression analysis was carried out with 25(OH)D and omentin-1, and 25(OH)D displayed a significant positive correlation (P = 0.0001). The optimal cut-off point for the serum omentin-1 concentration was 135.01 ng/mL. No significant correlation was determined between omentin-1 and body mass index, lipid profile, glucose, and insulin variables (P > 0.05). Conclusions: We showed significantly low concentrations of serum omentin-1 in obese adolescents with vitamin D deficiency. Serum omentin-1 can be employed as a biomarker in obese adolescents with vitamin D deficiency. | en |
| DOI | https://doi.org/10.5812/ijp-137958 | en |
| Keyword | Obesity | en |
| Keyword | Adolescent | en |
| Keyword | Vitamin D Deficiency | en |
| Keyword | Omentin-1 | en |
| Publisher | Brieflands | en |
| Title | Serum Omentin-1 Levels in Obese Adolescents with Vitamin D Deficiency: A Prospective Cross-sectional Study | en |
| Type | Research Article | en |
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