Comparing the COVID-19 Mortality Rate in Cancer Patients with and Without a History of Chemotherapy
| Author | Nasrin Bazgir | en |
| Author | Fakhredin Taghinezhad | en |
| Author | Hassan Nourmohammadi | en |
| Author | Golnaz Azami | en |
| Author | Iraj Ahmadi | en |
| Author | Aliashraf Mozafari | en |
| Orcid | Nasrin Bazgir [0000-0001-9635-3828] | en |
| Orcid | Fakhredin Taghinezhad [0000-0002-2566-5135] | en |
| Orcid | Hassan Nourmohammadi [0000-0002-5967-3395] | en |
| Orcid | Golnaz Azami [0000-0003-2588-3957] | en |
| Orcid | Aliashraf Mozafari [0000-0002-9962-3130] | en |
| Issued Date | 2022-10-31 | en |
| Abstract | Background: Patients with cancer are potentially vulnerable to COVID-19 infection due to the immune-compromised state of cancer or its treatment complications. Objectives: This study compared the COVID-19 mortality rate in cancer patients with and without a history of chemotherapy. Methods: This registry-based cohort study launched from March 2020 to March 2021 contains 2350 records in which 64 COVID-19 patients with cancer were included, of which 27 patients underwent the chemotherapy plan within eight weeks before confirmed COVID-19. In addition, age and sex were matched in patients without a history of cancer as a control group. Two groups of cancer patients with and without a history of chemotherapy compared to the control group using cox proportional hazard regression models in Stata.10 software. Results: Patients with cancer had a higher hazard for in-hospital mortality from COVID-19 infection (adjusted HR; 2.27, 95% CI: 1.25 - 4.13, P = 0.007) after adjusting for age, sex, body mass index (BMI), and co-morbidities. Our result showed no significant association between chemotherapy and control groups (adjusted HR; 1.65, 95% CI: 0.60 - 4.56, P = 0.33). Conclusions: Patients with cancer faced a risk of mortality from COVID-19 two times higher than those without cancer. However, chemotherapy did not increase the mortality following COVID-19 infection. | en |
| DOI | https://doi.org/10.5812/ijcm-128404 | en |
| Keyword | Drug Therapy | en |
| Keyword | COVID-19 | en |
| Keyword | SARS-CoV-2 Infection | en |
| Keyword | Neoplasm | en |
| Keyword | Chemotherapy | en |
| Publisher | Brieflands | en |
| Title | Comparing the COVID-19 Mortality Rate in Cancer Patients with and Without a History of Chemotherapy | en |
| Type | Research Article | en |
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