The effect of cyclosporine on asymmetric antibodies and serum transforming growth factor beta1 in abortion-prone model of mice CBA/J x DBA/2
| Author | Seyed Mohammad Moazzeni | en |
| Author | bizhan sadighi-moghaddam | en |
| Issued Date | 2015-09-30 | en |
| Abstract | Introduction: One of the common causes of recurrent spontaneous abortion is interference of immunological factors. Administration of cyclosporine, as an immunosuppressive drug, has reportedly reduc the rate of abortion in abortion-prone model of mice CBA/J mated DBA/2 male mice. On the other hand, asymmetric antibodies and TGF-β1 have been considered as an important factor in successful pregnancy outcomes. Intravaginal administration of TGF-β has also been reported to reduce the resorption rate in the same mouse model. In this study, the immunomodulatory effects of cyclosporine on serum level of asymmetric antibodies (AAbs) and T cell growth factor beta (TGF-β1) were investigated. Material and Methods: Female CBA/J mice were mated with male DBA/2. The pregnant females were divided into two groups: 1- test group received intraperitoneal injection of 1mg/kg cyclosporine (n=7), 2- control group received intraperitoneal injection of Phosphate Buffered Saline (PBS) (n=7). Both groups received treatments on the 5th day of pregnancy. Serum samples were collected on the 13.5th day of pregnancy, when the percentage of abortion was also calculated. Results: The percentage of AAbs and abortion rate were significantly reduced in cyclosporine group (P0.05). Conclusion: Our study showed that despite the significant reduction in percentage of AAbs and no significant difference in serum level of TGF-β1, the abortion rate was markedly reduced in cyclosporine group. So other mechanisms of immunomodulation and reduction of abortion rate except asymmetric antibodies and TGF-β1 should be involved in this mouse model following cyclosporine administration. | en |
| DOI | https://doi.org/ | en |
| Keyword | Recurrent Spontaneous Abortion | en |
| Keyword | Asymmetric Antibodies | en |
| Keyword | Cyclosporine | en |
| Keyword | سقط مکرر خودبهخودی | en |
| Keyword | آنتیبادی نامتقارن | en |
| Keyword | سیکلوسپورین | en |
| Publisher | Brieflands | en |
| Title | The effect of cyclosporine on asymmetric antibodies and serum transforming growth factor beta1 in abortion-prone model of mice CBA/J x DBA/2 | en |
| Type | Research Article | en |
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