Oral Diphenhydramine-Midazolam Versus Oral Diphenhydramine for Pediatric Sedation in the Emergency Department
| Author | Samad EJ Golzari | en |
| Author | Kavous Shahsavari Nia | en |
| Author | Majid Sabahi | en |
| Author | Hassan Soleimanpour | en |
| Author | Ata Mahmoodpoor | en |
| Author | Saeid Safari | en |
| Author | Nooshin Milanchian | en |
| Issued Date | 2014-02-01 | en |
| Abstract | Background: Sedation is defined as the attenuation of CNS reflexes following usage of some medications; this can be used to provide patient comfort with no undesirable loss of consciousness. Objectives: This study focused on the efficacy of oral diphenhydramine-midazolam versus oral diphenhydramine for pediatric sedation in the emergency department. Patients and Methods: One hundred children up to 13 years, referred to the emergency department for suturing their wounds, were randomized into two groups. Group I received 1.25 mg/kg diphenhydramine and group II received 1.25 mg/kg diphenhydramine plus 0.5 mg/kg midazolam, orally. Later, the drug compliance and anxiety were categorized. Child behavior patterns such as crying, consciousness and movement were recorded. Two weeks after discharge, subjects were followed-up for any experience of complication. Results: The maximum time to achieve the optimal sedation was 16.13 ± 4.78 minutes in group I and 7.1 ± 2.49 minutes in group II (P < 0.0001). Behavior study of the children was obtained by phone calls to their parents 2 weeks after discharge; restlessness and insomnia were less frequently seen in group II in comparison with group I (P < 0.0001) Conclusions: Combination of diphenhydramine-midazolam in comparison with only diphenhydramine, provides a higher quality of sedation, with fewer complications before diagnostic and therapeutic procedures in children. | en |
| DOI | https://doi.org/10.17795/compreped-17946 | en |
| Keyword | Diphenhydramine | en |
| Keyword | Midazolam | en |
| Keyword | Sedation | en |
| Keyword | Children | en |
| Publisher | Brieflands | en |
| Title | Oral Diphenhydramine-Midazolam Versus Oral Diphenhydramine for Pediatric Sedation in the Emergency Department | en |
| Type | Research Article | en |
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