Omentin-1 Levels and Non-alcoholic Fatty Liver Disease in Obese Adolescents
| Author | Emine Turkkan | en |
| Author | Huseyin Dag | en |
| Author | Okan Dikker | en |
| Author | Nevin Cetin Dag | en |
| Author | Alper Kacar | en |
| Author | Soner Sazak | en |
| Orcid | Emine Turkkan [0000-0002-5126-7843] | en |
| Orcid | Huseyin Dag [0000-0001-7596-7687] | en |
| Orcid | Okan Dikker [0000-0002-9153-6139] | en |
| Orcid | Nevin Cetin Dag [0000-0002-9471-5650] | en |
| Orcid | Alper Kacar [0000-0001-7577-5386] | en |
| Orcid | Soner Sazak [0000-0003-0233-6950] | en |
| Issued Date | 2021-10-31 | en |
| Abstract | Background: Omentin-1 is an adipocytokine secreted from visceral adipose tissue that is thought to increase insulin sensitivity. Non-alcoholic fatty liver disease (NAFLD) is a comparatively extensive problem in obese adolescents. Decreased omentin-1 levels have been reported in obese patients, but the relationship between NAFLD and omentin-1 is contradictory. Objectives: We aimed to evaluate the omentin-1 levels in the sera of obese adolescents with and without NAFLD and compare them with each other. Methods: In this study, a total of 88 adolescents (56 obese and 32 normal-weight) were enrolled. Abdominal ultrasonography (US) identified 28 obese adolescents with grade 2 - 3 hepatosteatosis constituting the NAFLD group and 28 without hepatosteatosis on US constituting the non-NAFLD group. The control group included 32 age- and gender-matched cases without hepatosteatosis and with normal percentile body mass index (BMI). Serum omentin-1 levels were evaluated and compared. Results: The mean age of the research group was 12.72 ± 1.91 years. Unsurprisingly, BMI, glycated hemoglobin (HbA1c), liver transaminases (AST, ALT), total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL), homeostatic model assessment for insulin resistance (HOMA-IR), and insulin rates were noticeably elevated in obese adolescents compared to controls (P < 0.05). However, omentin-1 and high-density lipoprotein cholesterol (HDL) levels were remarkably lower in the obese group (P < 0.05). No significant difference was found between the NAFLD and non-NAFLD groups regarding omentin-1, HbA1c, glucose, urea, creatinine, AST, C-reactive protein (CRP), total cholesterol, triglyceride, HDL, LDL, thyroid stimulating hormone, 25-hydroxyvitamin D3, HOMA-IR, and insulin. The BMI and ALT grades of the non-NAFLD group were notably lower than the NAFLD group (P < 0.05). While there was no significant difference between omentin-1 and other parameters in obese adolescents without NAFLD (P > 0.05), we found a significant difference between omentin-1 and BMI, AST, ALT, HOMA-IR, and insulin values in obese adolescents with NAFLD (P < 0.05). Conclusions: Omentin-1 levels were decreased in obese adolescents regardless of the presence of NAFLD. However, in obese patients with NAFLD, there was a significant difference between omentin-1 and several markers of obesity and insulin resistance. | en |
| DOI | https://doi.org/10.5812/ijp.117353 | en |
| Keyword | Omentin-1 | en |
| Keyword | Obesity | en |
| Keyword | Non-alcoholic Fatty Liver Disease | en |
| Keyword | Adolescents | en |
| Publisher | Brieflands | en |
| Title | Omentin-1 Levels and Non-alcoholic Fatty Liver Disease in Obese Adolescents | en |
| Type | Research Article | en |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- ijp-31-5-117353.pdf
- Size:
- 149.9 KB
- Format:
- Adobe Portable Document Format
- Description:
- Article/s PDF