Efficacy of Chloral Hydrate and Promethazine for Sedation during Electroencephalography in Children; a Randomised Clinical Trial

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AuthorRazieh Fallahen
AuthorSharam Jalilien
AuthorMotahhareh Golestanen
AuthorSedighah Akhavan Karbasien
AuthorMohammad-Hosein Jarahzadehen
Issued Date2013-02-28en
AbstractObjective: The purpose of this study was to compare efficacy and safety of oral chloral hydrate (CH) and promethazine (PZ) for sedation during electroencephalography (EEG) in children. Methods: In a parallel single-blinded randomized clinical trial, sixty 1-10 year old children referred to EEG Unit of Shahid Sadoughi Hospital from January 2010 to February 2011 in Yazd, Iran, were evaluated. They were randomized to receive orally 70 mg/kg chloral hydrate or promethazine 1 mg/kg. The primary outcome was efficacy in adequate sedation and successful recording of EEG. Secondary outcome included clinical side effects, time from administration of the drug to adequate sedation, caregiver’s satisfaction on a Likert scale, and total stay time in EEG Unit. Findings: Twenty four cases with mean age 2.9±1.9 years were evaluated. Adequate sedation (Ramsay sedation score of four) was obtained in 43.3% of PZ and 100% of CH group (P=0.00001). Also in 70% of PZ and 96.7% of CH group, EEG was successfully recorded (P=0.006). So, CH was a more effective drug. In CH group, EEG was performed in shorter time after taking the drug (32.82±9.6 vs 52.14±22.88 minutes, Pen
DOIhttps://doi.org/en
KeywordChloral hydrateen
KeywordPromethazineen
KeywordEEGen
KeywordSedationen
PublisherBrieflandsen
TitleEfficacy of Chloral Hydrate and Promethazine for Sedation during Electroencephalography in Children; a Randomised Clinical Trialen
TypeResearch Articleen

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