A Comprehensive Review of <i>Punica</i><i>granatum</i> (Pomegranate) Properties in Toxicological, Pharmacological, Cellular and Molecular Biology Researches

Simple item page
AuthorHamid Reza Rahimien
AuthorMohammad Arastooen
AuthorSeyed Nasser Ostaden
Issued Date2012-04-30en
AbstractPunica granatum (Pg), commonly known as pomegranate (Pg), is a member of the monogeneric family, Punicaceae, and is mainly found in Iran which is considered to be its primary centre of origin. Pg and its chemical components possess various pharmacological and toxicological properties including antioxidant, anti-inflammatory (by inhibiting pro-inflammatory cytokines), anti-cancer and anti-angiogenesis activities. They also show inhibitory effects on invasion/motility, cell cycle, apoptosis, and vital enzymes such as cyclooxygenase (COX), lipooxygenase (LOX), cytochrome P450 (CYP450), phospholipase A2 (PLA2), ornithine decarboxylase (ODC), carbonic anhydrase (CA), 17beta-hydroxysteroid dehydrogenase (17β-HSDs) and serine protease (SP). Furthermore, they can stimulate cell differentiation and possess anti-mutagenic effects. Pg can also interfere with several signaling pathways including PI3K/AKT, mTOR, PI3K, Bcl-X, Bax, Bad, MAPK, ERK1/2, P38, JNK, and caspase. However, the exact mechanisms for its pharmacological and toxicological properties remain to be unclear and need further evaluation. These properties strongly suggest a wide range use of Pg for clinical applications. This review will discuss the areas for which Pg has shown therapeutic properties in different mechanisms.en
DOIhttps://doi.org/10.22037/ijpr.2012.1148en
KeywordPunica granatumen
KeywordChemical componentsen
KeywordToxicological propertiesen
KeywordSignaling pathwayen
KeywordClinical applicationsen
PublisherBrieflandsen
TitleA Comprehensive Review of <i>Punica</i><i>granatum</i> (Pomegranate) Properties in Toxicological, Pharmacological, Cellular and Molecular Biology Researchesen
TypeOriginal Articleen

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
IJPR-011-385.pdf
Size:
715.7 KB
Format:
Adobe Portable Document Format
Description:
Article/s PDF
Download

Collections

Iranian Journal of Pharmaceutical Research