GB Virus C infection in Patients With HIV/Hepatitis C Virus Coinfection: Improvement of the Liver Function in Chronic Hepatitis C
| Author | Yue Feng | en |
| Author | Li Liu | en |
| Author | Yue-Mei Feng | en |
| Author | Wenhua Zhao | en |
| Author | Zheng Li | en |
| Author | A-Mei Zhang | en |
| Author | Yuzhu Song | en |
| Author | Xueshan Xia | en |
| Issued Date | 2014-03-01 | en |
| Abstract | Background: Previous studies in patients with hepatitis C virus (HCV)/HIV coinfection have shown that the presence of GBV-C is associated with significantly less compensated and decompensated cirrhosis, and an improvement in cirrhosis-free survival. Objectives: This study aimed to describe the effect of GBV-C in patients with chronic hepatitis C and HIV coinfection. Patients and Methods: We retrospectively studied 105 injecting drug users with chronic hepatitis C and HIV coinfection and 72 patients with chronic HCV mono-infections. Plasma samples were tested for GBV-C RNA with primers to the 5’untranslated region gene. HIV and HCV viral load, CD4+ and CD8+ cell count, and the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were tested in all patients. Results: GBV-C RNA was identified in 34 (32.38%) of the patients with HIV/HCV coinfection, and in 24 (33.33%) of the patients with HCV mono-infection. GBV-C infection was associated with significantly lower ALT and AST levels in patients with chronic hepatitis C and HIV coinfection, but not in those HCV mono-infections. The presence of GBV-C infection was not correlated with CD4+ and CD8+ cell count, gender, age, HIV load, HCV load, and HCV genotype. Conclusions: This study found that GBV-C infection has a high frequency among injecting drug users with HIV/HCV coinfection and HCV mono-infection in Yunnan, China. In patients with chronic hepatitis C and HIV coinfection, GBV-C RNA was associated with significantly lower ALT and AST levels, suggesting a beneficial effect of GBV-C infection on chronic hepatitis C. | en |
| DOI | https://doi.org/10.5812/hepatmon.14169 | en |
| URI | https://brieflands.com/journals/hepatmon/articles/15340 | en |
| Keyword | GB virus C | en |
| Keyword | Coinfection | en |
| Keyword | HIV | en |
| Keyword | Hepatitis C virus | en |
| Keyword | Liver Function Tests | en |
| Publisher | Brieflands | en |
| Title | GB Virus C infection in Patients With HIV/Hepatitis C Virus Coinfection: Improvement of the Liver Function in Chronic Hepatitis C | en |
| Type | Brief Report | en |
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