Effect of Propofol and Isoflurane on Postoperative Cognitive Dysfunction Following Elective Laminectomy Surgery in Adult Elderly Patients: A Randomized Controlled Trial Study
| Author | Shirin Motaghian | en |
| Author | Arash Heroabadi | en |
| Author | Keyvan Teymourei Khanesari | en |
| Author | Seyed Khalil Pestehei | en |
| Author | Mojtaba Marashi | en |
| Author | Reza Atef Yekta | en |
| Orcid | Seyed Khalil Pestehei [0000-0002-0538-8898] | en |
| Issued Date | 2023-10-31 | en |
| Abstract | Background: Postoperative cognitive dysfunction (POCD) is a significant complication, especially prevalent among elderly individuals following major surgical procedures. Objectives: This study aims to compare the impact of isoflurane and propofol on the occurrence of POCD in patients undergoing elective laminectomy surgery under general anesthesia. Methods: This randomized, double-blind clinical trial took place at Shariati Hospital in Tehran. Patients scheduled for elective laminectomy between December 2020 and November 2021 were enrolled in the study and randomized into 2 groups. Patients in Group P received a Propofol infusion, while patients in Group I were administered isoflurane. Cognitive function assessments were conducted using the Mini-Mental State Examination (MMSE) at 3-time points: Twelve hours before surgery and 6 and 24 hours after surgery. Results: The MMSE scores demonstrated a significant increase in the Propofol group compared to the Isoflurane group at the 6-hour and 24-hour post-surgery time points. However, no significant difference was observed at baseline before surgery (P = 0.04, P = 0.005, and P = 0.2, respectively). Conclusions: These findings suggest that the use of propofol for general anesthesia may be a favorable choice for surgical procedures in elderly patients. | en |
| DOI | https://doi.org/10.5812/ans-132837 | en |
| Keyword | Isoflurane | en |
| Keyword | Propofpl | en |
| Keyword | POCD | en |
| Publisher | Brieflands | en |
| Title | Effect of Propofol and Isoflurane on Postoperative Cognitive Dysfunction Following Elective Laminectomy Surgery in Adult Elderly Patients: A Randomized Controlled Trial Study | en |
| Type | Research Article | en |
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