GO/TiO₂ Hybrid Nanoparticles as New Photosensitizers in Photodynamic Therapy of A375 Melanoma Cancer Cells

Abstract

Photodynamic therapy (PDT) by nanoparticles (NPs) has been proposed as a new emerging therapeutic approach for the treatment of melanoma. In this study, the researchers investigate potential of photodynamic graphene oxide (GO)/TiO2 hybrid (GOT) NPs as new photosensitizers (PSs) in A375 melanoma cancer cell line. The results showed that while different concentrations of GOT NPs (1 - 100 μg/mL) were inert, their irradiation with visible-light induced growth arrest and cell death in A375 cells in a dose-despondent manner. These anti-cancer effects were accompanied by significant morphological changes, suggesting GOT NPs have a potential for further evaluation as new generation of PSs for cancer therapy.